Document Detail

Non-enzymic interactions of nicotinamide adenine dinucleotide, of some of its synthetic analogues and other compounds with orthophosphate.
MedLine Citation:
PMID:  40296     Owner:  NLM     Status:  MEDLINE    
Changes in the ultraviolet (UV) absorption spectra of nicotinamide adenine dinucleotide (NAD), of its synthetic analogues, and of adenosine and its derivatives in the presence of high concentrations of orthophosphate were studied. The role of the carboxamide group of the nicotinamide moiety of NAD on these spectral changes was investigated by replacing that group with an acetyl or aldehyde group. The effect of the 6-amino group of the purine was investigated by studying the interaction of deamino-NAD and various adenosine derivatives with orthophosphate. 2,4-Dinitrophenol was also found to give a charge transfer complex with phosphate. Molar extinction coefficients (E) and association constants (K) of these charge transfer reactions were determined.
F Ungar; B Ungar; S G Alivisatos; A D Mosnaim; M E Wolf
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  25     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-12-27     Completed Date:  1979-12-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-8     Citation Subset:  IM    
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MeSH Terms
Adenine Nucleotides
Chemical Phenomena
Hydrogen-Ion Concentration
NAD* / analogs & derivatives*
Reg. No./Substance:
0/Adenine Nucleotides; 0/Phosphates; 53-84-9/NAD; 58-61-7/Adenosine

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