Document Detail

Non-competitive inhibition of kainate-induced currents by diethylstilbestrol in acutely isolated mouse CA1 hippocampal neurons.
MedLine Citation:
PMID:  11128047     Owner:  NLM     Status:  MEDLINE    
The effect of a synthetic estrogen, diethylstilbestrol (DES), on kainate-induced currents was investigated in the hippocampal CA1 pyramidal neurons acutely dissociated from the mice using the nystatin-perforated patch-clamp recording configuration under voltage-clamp conditions. DES inhibited the current evoked by 100 microM kainate in a concentration-dependent manner with a half-maximum inhibitory concentration of 8.8 microM. The action of DES was voltage-independent. Since DES produced a suppression of the maximum response of the kainate concentration-response curve, the inhibition by DES of the kainate-induced current appears to be non-competitive.
H Ishibashi; S Okuya; H Shimada; K Takahama
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  84     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  225-8     Citation Subset:  IM    
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
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MeSH Terms
Diethylstilbestrol / pharmacology*
Drug Interactions
Estrogens, Non-Steroidal / pharmacology
Excitatory Amino Acid Agonists / pharmacology*
Hippocampus / drug effects*,  physiology
Kainic Acid / antagonists & inhibitors,  pharmacology*
Neurons / drug effects*,  physiology
Patch-Clamp Techniques
Reg. No./Substance:
0/Estrogens, Non-Steroidal; 0/Excitatory Amino Acid Agonists; 487-79-6/Kainic Acid; 56-53-1/Diethylstilbestrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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