| Non-competitive inhibition of GABA currents by phenothiazines in cultured chick spinal cord and rat hippocampal neurons. | |
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MedLine Citation:
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PMID: 2903473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The gamma-aminobutyric acid (GABA) inhibiting properties of several classes of antipsychotic medications were studied using gigaseal whole-cell voltage-clamp techniques in cultured chick spinal cord and rat hippocampal neurons. At doses above 1 microM trifluoperazine, chlorpromazine and thioridazine blocked GABA currents in a non-competitive fashion decreasing the maximal transmitter response without altering the half-maximal effective concentration. In contrast, haloperidol was ineffective against GABA at concentrations up to 100 microM. Among the agents studied trifluoperazine was the most potent GABA inhibitor with half maximal effect at 12 microM. Trifluoperazine (100 microM) also inhibited glycine-gated chloride currents in spinal cord neurons to an extent comparable to GABA (85 +/- 6% inhibition) but reduced glutamate currents by less than 35% in either spinal cord or hippocampal neurons. |
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Authors:
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C F Zorumski; J Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 92 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-11-30 Completed Date: 1988-11-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 86-91 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipsychotic Agents / pharmacology* Cells, Cultured Chick Embryo Chlorpromazine / pharmacology Hippocampus / cytology, drug effects, physiology* Membrane Potentials / drug effects Phenothiazines / pharmacology* Rats Spinal Cord / cytology, drug effects, physiology* Thioridazine / pharmacology Trifluoperazine / pharmacology gamma-Aminobutyric Acid / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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MH00630/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Phenothiazines; 117-89-5/Trifluoperazine; 50-52-2/Thioridazine; 50-53-3/Chlorpromazine; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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