Document Detail


Non-coding transcription SETs up regulation.
MedLine Citation:
PMID:  23147798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An abundance of long non-coding RNA (lncRNA) present in most species from yeast to human are involved in transcriptional regulation, dosage compensation and imprinting. This underscores the importance of lncRNA as functional RNA despite the fact that they do not produce proteins. Two recent papers in Cell have demonstrated that transcription of the non-conserved lncRNAs, but not the RNAs themselves, is necessary to introduce co-transcriptional regulatory histone marks to regulate gene expression.
Authors:
Swaminathan Venkatesh; Jerry L Workman
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Publication Detail:
Type:  Journal Article     Date:  2012-11-13
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  311-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromatin / metabolism
Gene Expression Regulation / genetics,  physiology
Histones / metabolism
Humans
RNA, Long Noncoding / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Chromatin; 0/Histones; 0/RNA, Long Noncoding
Comments/Corrections

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