| Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. | |
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MedLine Citation:
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PMID: 18772268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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17beta-estradiol binds to the estrogen receptor (ER) to activate gene expression or repression and this involves both genomic (nuclear) and non-genomic (extranuclear) pathways. Genomic pathways include the classical interactions of ligand-bound ER dimers with estrogen-responsive elements in target gene promoters. ER-dependent activation of gene expression also involves DNA-bound ER that subsequently interacts with other DNA-bound transcriptions factors and direct ER-transcription factor (protein-protein) interactions where ER does not bind promoter DNA. Ligand-induced activation of ER/specificity protein (Sp) and ER/activating protein-1 [(AP-1); consisting of jun/fos] complexes are important pathways for modulating expression of a large number of genes. This review summarizes some of the characteristics of ER/Sp- and ER/AP-1-mediated transactivation, which are dependent on ligand structure, cell context, ER-subtype (ERalpha and ERbeta), and Sp protein (SP1, SP3, and SP4) and demonstrates that this non-classical genomic pathway is also functional in vivo. |
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Authors:
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Stephen Safe; Kyounghyun Kim; Kyoungkim Kim |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2008-09-04 |
Journal Detail:
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Title: Journal of molecular endocrinology Volume: 41 ISSN: 1479-6813 ISO Abbreviation: J. Mol. Endocrinol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2009-01-27 Revised Date: 2011-04-04 |
Medline Journal Info:
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Nlm Unique ID: 8902617 Medline TA: J Mol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 263-75 Citation Subset: IM |
Affiliation:
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Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas 77843-4466, USA. ssafe@cvm.tamu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line, Tumor Estradiol / metabolism* Gene Expression Regulation* Humans Ligands Receptors, Estrogen / genetics, metabolism* Signal Transduction / physiology* Sp1 Transcription Factor / genetics, metabolism Transcription Factor AP-1 / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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ES04917/ES/NIEHS NIH HHS; P42 ES004917-190007/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Receptors, Estrogen; 0/Sp1 Transcription Factor; 0/Transcription Factor AP-1; 50-28-2/Estradiol |
| Comments/Corrections | |
Erratum In:
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J Mol Endocrinol. 2009 Apr;42(4):359 Note: Kim, Kyoungkim [corrected to Kim, Kyounghyun] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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