Document Detail


Non-cirrhotic portal hypertension with large regenerative nodules: a diagnostic challenge.
MedLine Citation:
PMID:  21633664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Non-cirrhotic portal hypertension is a poorly understood condition characterized by portal hypertension in the absence of conventional hepatic cirrhosis and described in association with blood coagulation disorders, myeloproliferative and immunological diseases and with exposure to toxic drugs. Very recently, precise classification criteria have been proposed in order to define four distinct subcategories. The present case highlights how the clinical presentation, the confounding results from imaging studies, and the difficulties in the histological evaluation often render cases of non-cirrhotic portal hypertension a real diagnostic challenge. It also underscores the classification problems which can be faced once this diagnosis is performed. Indeed, the different subcategories proposed result from the prevalent subtypes in a spectrum of hepatic regenerative responses to a variety of injuries determining microcirculatory disturbances. More flexibility in classification should derive from this etiopathogenic background.
Authors:
Umberto Vespasiani Gentilucci; Paolo Gallo; Giuseppe Perrone; Riccardo Del Vescovo; Giovanni Galati; Sandro Spataro; Chiara Mazzarelli; Adriano Pellicelli; Antonella Afeltra; Antonio Picardi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-10-11     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  2580-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Humans
Hypertension, Portal / classification*,  diagnosis*,  pathology
Liver / pathology*
Liver Regeneration*
Magnetic Resonance Imaging
Male
Middle Aged
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