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Non-calcified coronary atherosclerotic plaque visualization on CT: effects of contrast-enhancement and lipid-content fractions.
MedLine Citation:
PMID:  23324971     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Computed tomography (CT) may characterize lipid-rich and presumably rupture-prone non-calcified coronary atherosclerotic plaque based on its Hounsfield-Unit (HU), but still inconclusively. This study aimed to evaluate factors influencing the HU-value of non-calcified plaque using software simulation. Several realistic virtual plaqueburdened coronary phantoms were constructed at 5 μm resolution. CT scanning was simulated with settings resembling a 64-row multi-detector CT (64-MDCT) and reconstructed at 64-MDCT (0.4 mm) and MicroCT (48 μm) resolutions. Influences of lumen contrast-enhancement, stenosis-grades, and plaque compositions on plaque visualization were analyzed. Lumen contrast-enhancement and mean plaque HU-value were positively correlated (R(2) > 0.92), with approximately the same slopes for all plaque compositions. Percentage lipid-content and mean plaque HU-value were negatively correlated (R(2) > 0.98). Stenosis-grade and noise had minimal influence on the correlations. Influence of lumen contrast-enhancement on plaque HU-value was following a specific exponentially declining pattern (y = Ae(-λx) + c) from the lumen border until 2-pixel radius. Outside 2-pixel radius, plaque HU-values deviated maximally 5 HU from non-contrast-enhanced reference. Thus, to avoid lumen contrast-enhancement influence, plaques should be measured outside 2-pixel radius from the lumen border. Based on the patterns found, a lumen influence correction algorithm may be developed. HU-based plaque percentage lipid-content determination might serve as an alternative plaque characterization method. However, its applicability is still hindered by many inherent limitations.
Authors:
Wisnumurti Kristanto; Peter M A van Ooijen; Marcel J W Greuter; Jaap M Groen; Rozemarijn Vliegenthart; Matthijs Oudkerk
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  -     ISSN:  1875-8312     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Radiology, Center for Medical Imaging-North East Netherlands, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700RB, Groningen, The Netherlands.
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