Document Detail


Non-blood contacting electro-hydraulic artificial myocardium (EHAM) improves the myocardial tissue perfusion.
MedLine Citation:
PMID:  16055971     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Artificial heart (AH) and ventricular assist devices (VAD) are widely used in the clinical setting to assist severe heart failure patients. The concept of direct cardiac compression (DCC) has been in use for several decades and has advantages over intravascular VAD. The process involves compressing the dysfunctional heart from its epicardial surface to avoid the thromboembolic events and decrease the complications and mortality. An Electro-hydraulic Artificial Myocardium (EHAM) system was designed and fabricated by Tohoku University. This system may assist cardiac contraction and create pulsatile blood flow. The aim of this study was to clearly define the hemodynamic efficiency of the EHAM system in myocardial tissue perfusion during its application in acute animal experiment. Eight healthy adult goats were used; left lateral thoracotomy was performed and the chest was opened by the resection of the 4th and 5th ribs. Hemodynamic parameters including ECG, blood pressure and cardiac output were continuously monitored. Myocardial tissue perfusion was measured by using Omega flow laser fiber attached to the surface of the heart. During the EHAM compression, and increase in blood pressure and myocardial tissue perfusion was observed in all animals when compared with pre-assisted mode. To conclude, EHAM effectively improves myocardial tissue perfusion and increases the pressure on the initiation of direct cardiac compression immediately. Thus it can be a potentially valuable adjunct in the management of severe heart failure.
Authors:
Qingtian Wang; Tomoyuki Yambe; Yasuyuki Shiraishi; Xudong Duan; Makoto Yoshizawa; Kouichi Tabayashi; Shinichi Nitta; Mitsuo Umezu
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Technology and health care : official journal of the European Society for Engineering and Medicine     Volume:  13     ISSN:  0928-7329     ISO Abbreviation:  Technol Health Care     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-01     Completed Date:  2005-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9314590     Medline TA:  Technol Health Care     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Affiliation:
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. qingtian@idac.tohoku.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Artificial Organs*
Blood Circulation
Cardiac Output, Low / physiopathology,  therapy
Goats
Myocardial Contraction
Myocardial Reperfusion / instrumentation*

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