Document Detail


Non-autophagic roles of autophagy-related proteins.
MedLine Citation:
PMID:  23337627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autophagy and autophagy-related processes are fundamentally important in human health and disease. These processes are viewed primarily as cellular degradative pathways that recycle macromolecules and dysfunctional or redundant organelles into amino acids, sugars and lipids, especially during starvation. However, the ubiquitin-like autophagy proteins and other components of the autophagic machinery additionally participate in cellular reprogramming. We highlight these non-autophagic roles of autophagy proteins with the aim of drawing attention to this growing, but unexplored, research topic. We focus on the non-autophagic functions of autophagy proteins in cell survival and apoptosis, modulation of cellular traffic, protein secretion, cell signalling, transcription, translation and membrane reorganization.
Authors:
Suresh Subramani; Vivek Malhotra
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-22
Journal Detail:
Title:  EMBO reports     Volume:  14     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-07-22     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / physiology
Adipogenesis
Animals
Autophagy*
Exocytosis
Host-Pathogen Interactions
Humans
Intracellular Signaling Peptides and Proteins / physiology*
Microfilament Proteins / physiology
Microtubule-Associated Proteins / physiology
Protein Transport
Signal Transduction*
Small Ubiquitin-Related Modifier Proteins / physiology
Ubiquitin-Activating Enzymes / physiology
Grant Support
ID/Acronym/Agency:
GM 069373/GM/NIGMS NIH HHS; R01 GM069373/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/ATG12 protein, human; 0/ATG5 protein, human; 0/Adaptor Proteins, Signal Transducing; 0/GABARAPL2 protein, human; 0/Intracellular Signaling Peptides and Proteins; 0/Microfilament Proteins; 0/Microtubule-Associated Proteins; 0/Small Ubiquitin-Related Modifier Proteins; EC 6.3.2.19/Atg7 protein, human; EC 6.3.2.19/Ubiquitin-Activating Enzymes
Comments/Corrections

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