| Non-apoptotic roles for death-related molecules: When mitochondria chose cell fate. | |
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MedLine Citation:
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PMID: 22342457 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The decision between death and survival is a difficult phase of a cell life. It may depend on the intensity of a stress stimulus, on the presence of invasive pathogens, or on specific signals from neighbouring cells. Death-related molecules are being shown to possess different, and sometimes opposite roles, which they play also according to a number of environmental clues. In this review, we will analyse some of these molecules and their roles, with particular regard to mitochondria-related factors, such as BCL2 family members, the apoptosome components, the autophagy/death cross-talkers and molecules regulating mitochondrial structure and functions. Turning the double-edged swords of death molecules into plougshares may turn out to be strategically crucial in molecular oncology. |
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Authors:
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Flavie Strappazzon; Silvia Campello; Francesco Cecconi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-8 |
Journal Detail:
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Title: Experimental cell research Volume: - ISSN: 1090-2422 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373226 Medline TA: Exp Cell Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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IRCCS Fondazione Santa Lucia, 00143 Rome, Italy; Dulbecco Telethon Institute at the Department of Biology, University of Tor Vergata, 00133 Rome, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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