Document Detail

Non-antiarrhythmic drugs for the prevention of cardiac arrhythmias.
MedLine Citation:
PMID:  15875506     Owner:  NLM     Status:  MEDLINE    
It is noteworthy that drugs having a significant impact in preventing arrhythmias (atrial or ventricular) are those with no direct specific antiarrhythmic electrophysiologic properties. Specifically, drugs able to interfere with the renin-angiotensin system and the n-3 fatty acids seem to play a relevant role as antiarrhythmics, even if they do not act in the typical manner. Angiotensin-converting enzyme (ACE) inhibitors decrease the incidence of arrhythmias in patients with decreased left ventricular function. The main reduction is linked to a decrease of ventricular arrhythmias, while several studies have suggested that ACE-inhibitors may also decrease the burden of atrial fibrillation. Furthermore, many of angiotensin receptor blockers and spironolactone have been shown to have antiarrhythmic properties. n-3 polyunsaturated fatty acids (PUFAs) are known to be antiarrhythmic as well. Their effects on the fast voltage-dependent sodium current I(NA), inhibition of I(Ca2+) and the K+ channel modulation explain their antiarrhythmic properties. For these reasons the renin-angiotensin system blockade and the n-3 PUFA intake may provide simple and safe protection from cardiac arrhythmias.
Matteo Di Biase; Rossella Troccoli; Natale Daniele Brunetti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Italian heart journal : official journal of the Italian Federation of Cardiology     Volume:  6     ISSN:  1129-471X     ISO Abbreviation:  Ital Heart J     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-06     Completed Date:  2005-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100909716     Medline TA:  Ital Heart J     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
Cardiology Department, University of Foggia, Foggia, Italy.
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MeSH Terms
Aldosterone Antagonists / therapeutic use
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Arrhythmias, Cardiac / drug therapy*
Cardiovascular Agents / therapeutic use*
Fatty Acids, Omega-3 / therapeutic use
Receptors, Angiotensin / therapeutic use
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Cardiovascular Agents; 0/Fatty Acids, Omega-3; 0/Receptors, Angiotensin

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