| Non-antiarrhythmic drugs for the prevention of cardiac arrhythmias. | |
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MedLine Citation:
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PMID: 15875506 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is noteworthy that drugs having a significant impact in preventing arrhythmias (atrial or ventricular) are those with no direct specific antiarrhythmic electrophysiologic properties. Specifically, drugs able to interfere with the renin-angiotensin system and the n-3 fatty acids seem to play a relevant role as antiarrhythmics, even if they do not act in the typical manner. Angiotensin-converting enzyme (ACE) inhibitors decrease the incidence of arrhythmias in patients with decreased left ventricular function. The main reduction is linked to a decrease of ventricular arrhythmias, while several studies have suggested that ACE-inhibitors may also decrease the burden of atrial fibrillation. Furthermore, many of angiotensin receptor blockers and spironolactone have been shown to have antiarrhythmic properties. n-3 polyunsaturated fatty acids (PUFAs) are known to be antiarrhythmic as well. Their effects on the fast voltage-dependent sodium current I(NA), inhibition of I(Ca2+) and the K+ channel modulation explain their antiarrhythmic properties. For these reasons the renin-angiotensin system blockade and the n-3 PUFA intake may provide simple and safe protection from cardiac arrhythmias. |
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Authors:
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Matteo Di Biase; Rossella Troccoli; Natale Daniele Brunetti |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Italian heart journal : official journal of the Italian Federation of Cardiology Volume: 6 ISSN: 1129-471X ISO Abbreviation: Ital Heart J Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-05-06 Completed Date: 2005-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100909716 Medline TA: Ital Heart J Country: Italy |
Other Details:
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Languages: eng Pagination: 175-9 Citation Subset: IM |
Affiliation:
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Cardiology Department, University of Foggia, Foggia, Italy. dibiama@tiscali.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone Antagonists
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therapeutic use Angiotensin-Converting Enzyme Inhibitors / therapeutic use Arrhythmias, Cardiac / drug therapy* Cardiovascular Agents / therapeutic use* Fatty Acids, Omega-3 / therapeutic use Humans Receptors, Angiotensin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Cardiovascular Agents; 0/Fatty Acids, Omega-3; 0/Receptors, Angiotensin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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