| Non-anti-mitotic concentrations of taxol reduce breast cancer cell invasiveness. | |
| | |
MedLine Citation:
|
PMID: 19111674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Taxol is widely used in breast cancer chemotherapy. Its effects are primarily attributed to its anti-mitotic activity. Microtubule perturbators also exert antimetastatic activities which cannot be explained solely by the inhibition of proliferation. Voltage-dependent sodium channels (Na(V)) are abnormally expressed in the highly metastatic breast cancer cell line MDA-MB-231 and not in MDA-MB-468 cell line. Inhibiting Na(V) activity with tetrodotoxin is responsible for an approximately 0.4-fold reduction of MDA-MB-231 cell invasiveness. In this study, we focused on the effect of a single, 2-h application of 10 nM taxol on the two cell lines MDA-MB-231 and MDA-MB-468. At this concentration, taxol had no effect on proliferation after 7 days and on migration in any cell line. However it led to a 40% reduction of transwell invasion of MDA-MB-231 cells. There was no additive effect when taxol and tetrodotoxin were simultaneously applied. Na(V) activity, as assessed by patch-clamp, indicates that it was changed by taxol pre-treatment. We conclude that taxol can exert anti-tumoral activities, in cells expressing Na(V), at low doses that have no effect on cell proliferation. This effect might be due to a modulation of signalling pathways involving sodium channels. |
| | |
Authors:
|
Truong-An Tran; Ludovic Gillet; Sébastien Roger; Pierre Besson; Edward White; Jean-Yves Le Guennec |
Related Documents
:
|
3497894 - Effects of amiloride on hyperthermic cell killing of normal and thermotolerant mouse fi... 9043644 - Cell volume regulation in claviceps fusiformis. an animal-type na,k-atpase operating in... 1415564 - Cell volume regulation in rat thin ascending limb of henle's loop. 9075644 - Rapid swelling of a cho-k1 aspartate/glutamate transport mutant in hypo-osmotic medium. 7834114 - Cytocidal effect of high energy shock wave on tumour cells enhanced with larger dose an... 8760304 - Distinct p53-mediated g1/s checkpoint responses in two nih3t3 subclone cells following ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-26 |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: 379 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2009 Feb |
Date Detail:
|
Created Date: 2009-01-21 Completed Date: 2009-02-13 Revised Date: 2011-07-22 |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
|
Languages: eng Pagination: 304-8 Citation Subset: IM |
Affiliation:
|
Inserm, U921, 37000 Tours, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antineoplastic Agents, Phytogenic
/
pharmacology* Breast Neoplasms / pathology* Cell Line, Tumor Cell Proliferation / drug effects Humans Mitosis / drug effects Neoplasm Invasiveness Paclitaxel / pharmacology* Signal Transduction / drug effects Sodium Channels / drug effects Tubulin Modulators / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents, Phytogenic; 0/Sodium Channels; 0/Tubulin Modulators; 0/sodium channel protein type 5 subunit alpha; 33069-62-4/Paclitaxel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerev...
Next Document: Targeted disruption of the mouse Lipoma Preferred Partner gene.