Document Detail

Non-allergic rhinitis with eosinophils and mast cells constitutes a new severe nasal disorder.
MedLine Citation:
PMID:  18547476     Owner:  NLM     Status:  MEDLINE    
Three main types of inflammatory Non-Allergic Rhinitis (NAR) have been defined: NAR infiltrated by eosinophils (NARES), by mast cells (NARMA), and by neutrophils (NARNE). A new particular type has been characterized with current infiltration by eosinophils and mast cells (NARESMA). The aim of this study is to evaluate the clinical and functional characteristics in patients with NARES, NARMA, NARNE, and NARESMA and to define the latter. One hundred and seventy-six NAR patients were prospectively and consecutively evaluated: 52 patients with NARES, 38 with NARMA, 36 with NARNE, and 50 with NARESMA. Clinical features, Quality of Life (QoL), and rhinomanometry were evaluated in all of them. QoL was significantly different in the 4 groups. NARESMA patients had the worst QoL. Nasal function and QoL in NARESMA patients were significantly correlated. Significant associations were shown with both nasal polyps and asthma in NARESMA patients. This study provides the first evidence that NARESMA constitutes a new type of NAR and is a particularly severe disorder.
M Gelardi; A Maselli del Giudice; M L Fiorella; R Fiorella; C Russo; P Soleti; M Di Gioacchino; G Ciprandi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  21     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2008 Apr-Jun
Date Detail:
Created Date:  2008-06-12     Completed Date:  2008-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  IM    
Department of Ophthalmology and ENT, Faculty of Medicine, University of Bari, Italy.
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MeSH Terms
Eosinophils / pathology*
Mast Cells / pathology*
Middle Aged
Nasal Cavity / pathology
Nose Diseases / pathology*,  psychology
Prospective Studies
Quality of Life
Rhinitis / pathology*
Skin Tests

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