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Non-alcoholic partially reversible marchiafava-bignami disease: review and relation with reversible splenial lesions. A case report and literature review.
MedLine Citation:
PMID:  24206951     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Marchiafava-Bignami disease (MBD) is a rare pathological condition characterized by progressive demyelination and necrosis of the corpus callosum (CC). MBD occurs in patients with chronic alcoholism although a few non-alcoholic cases have been reported. We describe a non-alcoholic, depressed patient, who developed MBD after psycho-active drug abuse. Magnetic resonance imaging (MRI) disclosed bilateral, symmetric, hyperintense regions in the genu, body and splenium of the CC associated with increased water diffusivity. Clinical and MRI findings showed a partial recovery after tapering/modification of psycho-active drugs. We reviewed the nine cases of non-alcoholic MBD reported in the literature. We conclude that most cases should have been diagnosed as a reversible isolated splenial lesion (MERS), a recently described condition semiotically similar to MBD but with a specific localization, restricted water diffusivity and reversibility at MRI. In conclusion, MBD is an extremely rare condition in non-alcoholic patients and the use of MRI for distinguishing between MBD and MERS is crucial.
Authors:
M Caulo; C Briganti; F Notturno; G Committeri; P A Mattei; A Tartaro; M Gallucci; A Uncini
Publication Detail:
Type:  Journal Article     Date:  2009-03-23
Journal Detail:
Title:  The neuroradiology journal     Volume:  22     ISSN:  1971-4009     ISO Abbreviation:  Neuroradiol J     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2013-11-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101295103     Medline TA:  Neuroradiol J     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  -    
Affiliation:
Department of Clinical Sciences and Bioimaging and ITAB, "G. d'Annunzio" University; Chieti, Italy - caulo@unich.it.
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