Document Detail


Non-alcoholic duct destructive chronic pancreatitis.
MedLine Citation:
PMID:  9301509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The pathology of non-alcoholic chronic pancreatitis has not yet been sufficiently studied. AIMS: To identify the major changes of pancreatic tissue in patients surgically treated for non-alcoholic chronic pancreatitis. PATIENTS: Pancreatectomy specimens from 12 patients with non-alcoholic chronic pancreatitis, including four patients with autoimmune or related diseases (Sjögren's syndrome, primary sclerosing cholangitis, ulcerative colitis, and Crohn's disease), were reviewed. METHODS: Morphological changes were studied histologically and immunohistochemically (to type inflammatory cells) and compared with the pancreatic alterations found in 12 patients with alcoholic chronic pancreatitis. RESULTS: In patients with non-alcoholic chronic pancreatitis, with or without associated autoimmune or related diseases, pancreatic inflammation particularly involved the ducts, commonly resulting in duct obstruction and occasionally duct destruction. None of these features was seen in alcoholic chronic pancreatitis which, however, showed pseudocysts and calcifications. CONCLUSION: The pancreatic changes in patients with non-alcoholic chronic pancreatitis clearly differ from those with alcoholic chronic pancreatitis. The term chronic duct destructive pancreatitis is suggested for this type of pancreatic disease.
Authors:
N Ectors; B Maillet; R Aerts; K Geboes; A Donner; F Borchard; P Lankisch; M Stolte; J Lüttges; B Kremer; G Klöppel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gut     Volume:  41     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-09     Completed Date:  1997-10-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  263-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Catholic University Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Autoimmune Diseases / pathology*,  surgery
Chronic Disease
Female
Humans
Immunohistochemistry
Male
Middle Aged
Pancreatic Ducts / pathology*
Pancreatitis / pathology*,  surgery
Pancreatitis, Alcoholic / pathology,  surgery
Comments/Corrections
Comment In:
Gut. 1997 Aug;41(2):272-3   [PMID:  9301511 ]
Gut. 1999 Apr;44(4):579   [PMID:  10366291 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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