Document Detail

Non-ablative fractional resurfacing of surgical and post-traumatic scars.
MedLine Citation:
PMID:  19894367     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Non-ablative, fractional lasers generate microscopic columns of coagulated tissue through the epidermis and dermis to evoke a wound healing response. In this study, the authors examined the efficacy and safety of the non-ablative 1540 nm erbium:glass fractional laser in the treatment of surgical and post-traumatic scars. METHODS: Clinical studies were conducted on a range of surgical and post-traumatic scars with a 1540 nm erbium:glass fractional laser varying energy, pulse widths, treatment passes, and number of treatments. A histological study was conducted on a postsurgical scar to follow the time course of healing post-treatment and the impact of the fractional treatment on normalization of scar tissue, as compared to baseline histology of the scar. RESULTS: Histologic findings demonstrated rapid re-epithelialization of the epidermis within 72 hours of treatment. Remodeling of scar tissue with renewal and reorganization of collagen fibers in the dermis was noted two weeks post-treatment. Clinical subjects, with Fitzpatrick skin types II-V, received three to seven treatments with microbeam energies up to 60 mJ/pb and five passes. Relative to baseline, 73% of treated scars improved 50% or more and 43% improved 75% or more. Side effects included mild swelling (95% of subjects), erythema (94%) and purpura (5%), which all resolved within two to three days. Downtime was minimal-to-none for all subjects. CONCLUSION: These data illustrate the safety and efficacy of the 1540 nm erbium:glass fractional laser in the treatment of surgical and post-traumatic scars. Practitioners can vary energy and microbeam density in order to tailor the treatment to reflect the individual scar characteristics.
David B Vasily; Mary E Cerino; Ethel M Ziselman; S Tannous Zeina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  8     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2009-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  998-1005     Citation Subset:  IM    
Aesthetic Cosmetic and Laser Surgery Center, Bethlehem, PA 18018, USA.
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MeSH Terms
Cicatrix / etiology,  surgery*
Clinical Trials as Topic
Collagen / metabolism*
Laser Therapy / adverse effects,  methods*
Middle Aged
Postoperative Complications
Severity of Illness Index
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
7440-52-0/Erbium; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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