Document Detail

Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument.
MedLine Citation:
PMID:  20652388     Owner:  NLM     Status:  In-Data-Review    
Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu.
Masafumi Harada; Masako M Taki; Ayumi Nose; Hitoshi Kubo; Kenji Mori; Hiromu Nishitani; Tsuyoshi Matsuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  41     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-54     Citation Subset:  IM    
Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, 770-8509, Japan,
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