Document Detail


Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument.
MedLine Citation:
PMID:  20652388     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu.
Authors:
Masafumi Harada; Masako M Taki; Ayumi Nose; Hitoshi Kubo; Kenji Mori; Hiromu Nishitani; Tsuyoshi Matsuda
Related Documents :
8676168 - Simple partial status epilepticus: causes, treatment, and outcome in 47 patients.
19818938 - Neuropsychologic impairment in children with rolandic epilepsy.
19059978 - Limitations to plasticity of language network reorganization in localization related ep...
3363028 - Slow potential correlates of frontal function, psychosis, and negative symptoms.
24243078 - Presence of anemia in patients with celiac disease suggests more severe disease.
19181408 - Plasma homocysteine and cardiovascular risk in heart failure with and without cardioren...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  41     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  447-54     Citation Subset:  IM    
Affiliation:
Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, 770-8509, Japan, masafumi@medsci.tokushima-u.ac.jp.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Brief Report: Memory Performance on the California Verbal Learning Test - Children's Version in Auti...
Next Document:  Depressive symptoms among same-sex oriented young men: importance of reference group.