| Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument. | |
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MedLine Citation:
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PMID: 20652388 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Amino acids related to neurotransmitters and the GABAergic/glutamatergic system were measured using a 3 T-MRI instrument in 12 patients with autism and 10 normal controls. All measurements were performed in the frontal lobe (FL) and lenticular nuclei (LN) using a conventional sequence for n-acetyl aspartate (NAA) and glutamate (Glu), and the MEGA-editing method for GABA. The GABA level and [GABA]/[NAA] ratio were significantly lower (p < 0.01) in the FL, but not the LN, in patients with autism compared to normal controls. The [GABA]/[Glu] ratio in the FL was also significantly lower (p < 0.05) in the patients than in the normal controls, thus suggesting a possible abnormality in the regulation between GABA and Glu. |
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Authors:
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Masafumi Harada; Masako M Taki; Ayumi Nose; Hitoshi Kubo; Kenji Mori; Hiromu Nishitani; Tsuyoshi Matsuda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of autism and developmental disorders Volume: 41 ISSN: 1573-3432 ISO Abbreviation: J Autism Dev Disord Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7904301 Medline TA: J Autism Dev Disord Country: United States |
Other Details:
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Languages: eng Pagination: 447-54 Citation Subset: IM |
Affiliation:
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Department of Medical Imaging, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-Cho, Tokushima, 770-8509, Japan, masafumi@medsci.tokushima-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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