| Non-IgA mesangioproliferative glomerulonephritis: a benign entity? | |
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MedLine Citation:
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PMID: 22131234 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Non-IgA mesangioproliferative glomerulonephritis is a well recognized but less studied entity. The clinical manifestations, treatment response and long-term outcome have not been clearly defined.METHODS: This single-centre study included patients with biopsy-proven non-IgA mesangioproliferative glomerulonephritis who had been on regular follow-up for >3 years. Their clinical features at presentation, response to therapy and long-term renal outcome are addressed in this study.RESULTS: Nephrotic syndrome developed in 51 of 57 patients (89.4%). The majority of them-34 of 51(80%)-were steroid sensitive and had either infrequent or no relapse. However, steroid-dependent nephrotic syndrome occurred in eight patients (15.6%), while steroid resistance occurred in nine patients (17.6 %). Thirteen patients developed chronic kidney disease (CKD) with three progressing to end-stage renal disease, three to CKD Stage 4 and seven to CKD Stage 3.CONCLUSIONS: Non-IgA mesangioproliferative glomerulonephritis is a disease, which is not benign, and is associated with significant treatment-related morbidity. |
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Authors:
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Rajesh Waikhom; Dipankar Sarkar; Krishna Patil; Rajendra Pandey; Sanjay Dasgupta; Jayaprada Jadhav; Anila Abraham |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-29 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: - ISSN: 1460-2385 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Nephrology, IPGMER and SSKM Hospital, Kolkata, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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