Document Detail

Non-Hodgkin's lymphoma presenting as an endobronchial tumor: report of eight cases and literature review.
MedLine Citation:
PMID:  18175356     Owner:  NLM     Status:  MEDLINE    
Non-Hodgkin's lymphoma (NHL) involving the endobronchial tree is uncommon, and the initial presentation of NHL as an endobronchial tumor is extremely rare. In a series of 441 patients with newly diagnosed non-Hodgkin's lymphoma over a 7-year period, we reviewed the clinical features of eight patients who presented with an endobronchial tumor. All patients had local pulmonary disease without extrathoracic involvement. The major presenting symptoms were dyspnea, chest pain, cough, and hoarseness. None of the patients had systemic symptoms. Radiographs revealed lobar collapse in all cases. Five patients had mediastinal masses and three had isolated endobronchial lesions. Although MALT lymphoma is the most common primary pulmonary lymphoma, it was present in only one of our patients, while seven patients had aggressive lymphoma. All patients received chemotherapy. Six of the eight patients responded favorably to treatment with complete remission. The prognosis of patients with isolated endobronchial lymphoma is not worse than other local presentations of lymphoma. Bronchoscopic examination with biopsy is essential to differentiate these lesions from primary bronchongenic carcinoma.
Anna Solomonov; Tsila Zuckerman; Ludmila Goralnik; Yehudit Ben-Arieh; Jacob M Rowe; Mordechai Yigla
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  83     ISSN:  1096-8652     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  416-9     Citation Subset:  IM    
Division of Pulmonary Medicine, Rambam Health Care Campus and the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
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MeSH Terms
Aged, 80 and over
Antibodies, Monoclonal / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  therapeutic use
Bronchial Neoplasms / complications,  diagnosis*,  drug therapy,  pathology
Cyclophosphamide / administration & dosage
Diagnostic Imaging
Doxorubicin / administration & dosage
Dyspnea / etiology
Lymphoma, B-Cell, Marginal Zone / complications,  diagnosis,  drug therapy,  pathology
Lymphoma, Large B-Cell, Diffuse / complications,  diagnosis*,  drug therapy,  pathology
Mediastinal Neoplasms / complications,  diagnosis,  drug therapy,  pathology
Middle Aged
Neoplasms, Second Primary / pathology
Prednisolone / administration & dosage
Prednisone / administration & dosage
Pulmonary Atelectasis / etiology
Vincristine / administration & dosage
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/COP protocol 2; 0/VAP-cyclo protocol; 0/rituximab; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 53-03-2/Prednisone; 57-22-7/Vincristine

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