Document Detail


Non-Hodgkin's lymphoma in the elderly. A study of 602 patients aged 70 or older from a Danish population-based registry. The Danish LYEO-Study Group.
MedLine Citation:
PMID:  1616892     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within a 7-year period 1,597 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) were included in a Danish population-based NHL registry. Of these, 602 (38%) were aged 70 years or older (age range 70-94, median: 76.8). They represent the population defined as 'elderly' patients in the present study. The average annual incidence rate for this elderly patient population was 35.7/10(5), as compared with 6.6/10(5) for patients aged less than 70 (overall annual incidence: 9.5/10(5)). Localised cases (stage I and II) and extranodal manifestations were found more frequently among elderly patients. The most common sites of extranodal involvement were the stomach (21% of all extranodal cases) and the bone marrow (16%). Histologically, follicular centroblastic/centrocytic cases were found to be less frequent (p less than 0.01) in elderly patients as compared to their younger counterparts (less than 70 years), who in contrast had a lower occurrence of diffuse centroblastic cases (p less than 0.01). Overall 7-year survival for the elderly patient population was 35% (median 1.7 years), and for patients aged less than 70 it was 57%. This difference persisted after correction for apparently NHL-unrelated deaths (52% vs. 66%, respectively, p less than 0.0001). Elderly patients with poor prognosis were characterised by the following features identified in a Cox-regression model: hepatic involvement, presence of B-symptoms, high-grade histology and elevated s-LDH. The corresponding relative risk values were in the order 2.4, 2.2, 1.9 and 1.6.
Authors:
F d'Amore; H Brincker; B E Christensen; K Thorling; M Pedersen; J L Nielsen; E Sandberg; N T Pedersen; E Sørensen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  3     ISSN:  0923-7534     ISO Abbreviation:  Ann. Oncol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-08-04     Completed Date:  1992-08-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  379-86     Citation Subset:  IM    
Affiliation:
Dept. of Haematology, Odense University Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aging / physiology*
Denmark / epidemiology
Female
Humans
Incidence
Lymphoma, Non-Hodgkin / drug therapy,  epidemiology*,  pathology
Male
Prognosis

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