| A Non-Fluorinated Monobenzocyclooctyne for Rapid Copper-Free Click Reactions. | |
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MedLine Citation:
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PMID: 22190419 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We designed and synthesised carboxymethylmonobenzocyclooctyne (COMBO) through a four-step reaction pathway. COMBO is a new, structurally simple, non-fluorinated, and directly conjugable copper-free click reagent, which shows excellent reaction kinetics, as also evidenced by theoretical calculations. Additionally, the carboxylic acid appendage allows further conjugation to biomolecules or fluorescent labels. The utility of COMBO in bioorthogonal labelling schemes was demonstrated when a COMBO-containing fluorescent label was employed in glycan imaging of HeLa cells (metabolically modified to have azidosialic acid residues on their cell-surface glycans). |
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Authors:
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Balázs R Varga; Mihály Kállay; Krisztina Hegyi; Szabolcs Béni; Péter Kele |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
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Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1521-3765 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9513783 Medline TA: Chemistry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Institute of Chemistry, Eötvös Loránd University, H-1117 Pázmány Péter stny 1a, Budapest (Hungary), Fax: (+36) 1-372-2909 http://kelep.web.elte.hu. |
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