| Non FDG PET. | |
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MedLine Citation:
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PMID: 20541653 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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2- [(18)F]-fluoro-2-deoxy-D-glucose (FDG) is the radiopharmaceutical most frequently used for clinical positron emission tomography (PET). However, FDG cannot be used for many oncological, cardiological, or neurological conditions, either because the abnormal tissue does not concentrate it, or because the tissues under investigation demonstrate high physiological glucose uptake. Consequently, alternative PET tracers have been produced and introduced into clinical practice. The most important compounds in routine practice are (11)C-choline and (18)F-choline, mainly for the evaluation of prostate cancer; (1)C-methionine for brain tumours; (118)F-DOPA ((18)F-deoxiphenilalanine) for neuroendocrine tumours and movement disorders; (68)Ga-DOTANOC (tetraazacyclododecanetetraacetic acid-[1-Nal3]-octreotide) and other somatostatin analogues for neuroendocrine tumours; 11C-acetate for prostate cancer and hepatic masses and 18F-FLT (3-deoxy-3-fluorothymidine) for a number of malignant tumours. Another impetus for the development of new tracers is to enable the investigation of biological processes in tumours other than glucose metabolism. This is especially important in the field of response assessment, where there are new agents that are targeted more specifically at angiogenesis, hypoxia, apoptosis and other processes. |
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Authors:
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C Nanni; L Fantini; S Nicolini; S Fanti |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical radiology Volume: 65 ISSN: 1365-229X ISO Abbreviation: Clin Radiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1306016 Medline TA: Clin Radiol Country: England |
Other Details:
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Languages: eng Pagination: 536-48 Citation Subset: IM |
Copyright Information:
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Copyright 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Nuclear Medicine Unit, Policlinico S.Orsola, University of Bologna, Bologna, Italy. cristina.nanni@aosp.bo.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Choline
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diagnostic use Humans Methionine / diagnostic use Neoplasm Staging Neoplasms / radionuclide imaging* Positron-Emission Tomography / methods* Practice Guidelines as Topic Radioisotopes / diagnostic use* Radiopharmaceuticals / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 0/Radiopharmaceuticals; 62-49-7/Choline; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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