Document Detail


Non-Brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers.
MedLine Citation:
PMID:  18205424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Molecules associated with the outer surface of living cells exhibit complex, non-Brownian patterns of diffusion. In this report, supported lipid bilayers were patterned with nanoscale barriers to capture key aspects of this anomalous diffusion in a controllable format. First, long-range diffusion coefficients of membrane-associated molecules were significantly reduced by the presence of the barriers, while short-range diffusion was unaffected. Second, this modulation was more pronounced for large molecular complexes than for individual lipids. Surprisingly, the quantitative effect of these barriers on long-range lipid diffusion could be accurately simulated using a simple, continuum-based model of diffusion on a nanostructured surface; we thus describe a metamaterial that captures the properties of the outer membrane of living cells.
Authors:
Jones Tsai; Eileen Sun; Yuan Gao; James C Hone; Lance C Kam
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-01-19
Journal Detail:
Title:  Nano letters     Volume:  8     ISSN:  1530-6984     ISO Abbreviation:  Nano Lett.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-14     Completed Date:  2008-04-15     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation
Diffusion
Lipid Bilayers / chemistry*
Macromolecular Substances / chemistry
Materials Testing
Membrane Proteins / chemistry*
Models, Chemical*
Models, Molecular*
Molecular Conformation
Nanostructures / chemistry*,  ultrastructure*
Nanotechnology / methods*
Particle Size
Surface Properties
Grant Support
ID/Acronym/Agency:
PN2 EY016586/EY/NEI NIH HHS; PN2 EY016586/EY/NEI NIH HHS; PN2 EY016586-03/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Lipid Bilayers; 0/Macromolecular Substances; 0/Membrane Proteins
Comments/Corrections

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