Document Detail

Nomifensine test does not differentiate hyperprolactinemia associated with and without radiologic abnormalities in the sella turcica.
MedLine Citation:
PMID:  6927819     Owner:  NLM     Status:  MEDLINE    
A group of 17 hyperprolactinemic women was given 200 mg of nomifensine orally to evaluate its diagnostic potential to discriminate between tumors and nontumorous hyperprolactinemia. The nomifensine suppressive effect on prolactin serum levels was not significantly different between patients with or without enlargement of the sella turcica. A control group of 5 women with normal prolactin levels exhibited a nomifensine suppressive effect below 65% of the baseline prolactin level, which was significantly different from that in the hyperprolactinemic group. In conclusion it is confirmed that the nomifensine test provides no value in the early diagnosis of the prolactinoma.
E S Canales; C Cano; J Ablanedo; A Zárate
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone research     Volume:  15     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1981  
Date Detail:
Created Date:  1987-09-30     Completed Date:  1987-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
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MeSH Terms
Adenoma / diagnosis
Diagnosis, Differential
Hyperprolactinemia / blood*,  physiopathology,  radiography
Nomifensine / diagnostic use*,  pharmacology
Pituitary Neoplasms / diagnosis,  secretion
Prolactin / antagonists & inhibitors,  blood,  secretion
Sella Turcica / pathology,  radiography*
Reg. No./Substance:
24526-64-5/Nomifensine; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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