Document Detail


Nomegestrol acetate: clinical pharmacology
MedLine Citation:
PMID:  19749678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Progestogens are used in clinical practice in some conditions. Their effects depend on their chemical structure, pharmacokinetics, pharmacodynamics, with important differences among various progestogens. Generally, progestins are classified according to their parent molecule, of which often they keep some features. Derivatives of 19-nor-progesterone are characterized by high selectivity of action on progestin receptor. In particular, nomegestrol acetate (NomAc) shows an important progestational potency, neutral gluco-lipid profile, and antigonadotropic activity. It is used for treating menstrual cycle disorders and for hormone replacement therapy in menopause in association with an estrogen. In future, thanks to its antigonadotropic activity, NomAc will be used in estroprogestin combinations in fertile women, thus taking advantage of its tolerability profile and obtaining numerous non-contraceptive benefits as well.
Authors:
S Lello
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Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Minerva ginecologica     Volume:  61     ISSN:  0026-4784     ISO Abbreviation:  Minerva Ginecol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2010-02-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400731     Medline TA:  Minerva Ginecol     Country:  Italy    
Other Details:
Languages:  ita     Pagination:  459-63     Citation Subset:  IM    
Affiliation:
Dipartimento di Ginecologia Endocrinologica, Fisiopatologia della Menopausa e Osteoporosi, IDI-IRCCS, Roma, Italia. lellostefano@libero.it
Vernacular Title:
Nomegestrolo acetato: farmacologia clinica.
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MeSH Terms
Descriptor/Qualifier:
Biological Availability
Breast Diseases / drug therapy
Drug Therapy, Combination
Estradiol / administration & dosage,  analogs & derivatives
Female
Hormone Replacement Therapy
Humans
Hypothalamo-Hypophyseal System / drug effects
Megestrol / adverse effects,  chemistry,  pharmacokinetics,  pharmacology*,  therapeutic use
Menopause
Menstruation Disturbances / drug therapy
Metabolic Detoxication, Drug
Molecular Structure
Norpregnadienes / adverse effects,  chemistry,  pharmacokinetics,  pharmacology*,  therapeutic use
Ovulation Inhibition / drug effects
Protein Binding
Chemical
Reg. No./Substance:
0/Norpregnadienes; 3562-63-8/Megestrol; 50-28-2/Estradiol; 58652-20-3/nomegestrol acetate; 979-32-8/estradiol valerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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