| Nomegestrol acetate: clinical pharmacology | |
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MedLine Citation:
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PMID: 19749678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Progestogens are used in clinical practice in some conditions. Their effects depend on their chemical structure, pharmacokinetics, pharmacodynamics, with important differences among various progestogens. Generally, progestins are classified according to their parent molecule, of which often they keep some features. Derivatives of 19-nor-progesterone are characterized by high selectivity of action on progestin receptor. In particular, nomegestrol acetate (NomAc) shows an important progestational potency, neutral gluco-lipid profile, and antigonadotropic activity. It is used for treating menstrual cycle disorders and for hormone replacement therapy in menopause in association with an estrogen. In future, thanks to its antigonadotropic activity, NomAc will be used in estroprogestin combinations in fertile women, thus taking advantage of its tolerability profile and obtaining numerous non-contraceptive benefits as well. |
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Authors:
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S Lello |
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Publication Detail:
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Type: English Abstract; Journal Article; Review |
Journal Detail:
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Title: Minerva ginecologica Volume: 61 ISSN: 0026-4784 ISO Abbreviation: Minerva Ginecol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-14 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400731 Medline TA: Minerva Ginecol Country: Italy |
Other Details:
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Languages: ita Pagination: 459-63 Citation Subset: IM |
Affiliation:
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Dipartimento di Ginecologia Endocrinologica, Fisiopatologia della Menopausa e Osteoporosi, IDI-IRCCS, Roma, Italia. lellostefano@libero.it |
Vernacular Title:
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Nomegestrolo acetato: farmacologia clinica. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Availability Breast Diseases / drug therapy Drug Therapy, Combination Estradiol / administration & dosage, analogs & derivatives Female Hormone Replacement Therapy Humans Hypothalamo-Hypophyseal System / drug effects Megestrol / adverse effects, chemistry, pharmacokinetics, pharmacology*, therapeutic use Menopause Menstruation Disturbances / drug therapy Metabolic Detoxication, Drug Molecular Structure Norpregnadienes / adverse effects, chemistry, pharmacokinetics, pharmacology*, therapeutic use Ovulation Inhibition / drug effects Protein Binding |
| Chemical | |
Reg. No./Substance:
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0/Norpregnadienes; 3562-63-8/Megestrol; 50-28-2/Estradiol; 58652-20-3/nomegestrol acetate; 979-32-8/estradiol valerate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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