| Noise-induced hearing loss alters the temporal dynamics of auditory-nerve responses. | |
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MedLine Citation:
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PMID: 20696230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Auditory-nerve fibers demonstrate dynamic response properties in that they adapt to rapid changes in sound level, both at the onset and offset of a sound. These dynamic response properties affect temporal coding of stimulus modulations that are perceptually relevant for many sounds such as speech and music. Temporal dynamics have been well characterized in auditory-nerve fibers from normal-hearing animals, but little is known about the effects of sensorineural hearing loss on these dynamics. This study examined the effects of noise-induced hearing loss on the temporal dynamics in auditory-nerve fiber responses from anesthetized chinchillas. Post-stimulus-time histograms were computed from responses to 50-ms tones presented at characteristic frequency and 30 dB above fiber threshold. Several response metrics related to temporal dynamics were computed from post-stimulus-time histograms and were compared between normal-hearing and noise-exposed animals. Results indicate that noise-exposed auditory-nerve fibers show significantly reduced response latency, increased onset response and percent adaptation, faster adaptation after onset, and slower recovery after offset. The decrease in response latency only occurred in noise-exposed fibers with significantly reduced frequency selectivity. These changes in temporal dynamics have important implications for temporal envelope coding in hearing-impaired ears, as well as for the design of dynamic compression algorithms for hearing aids. |
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Authors:
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Ryan E Scheidt; Sushrut Kale; Michael G Heinz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-07 |
Journal Detail:
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Title: Hearing research Volume: 269 ISSN: 1878-5891 ISO Abbreviation: Hear. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-12-28 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 7900445 Medline TA: Hear Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 23-33 Citation Subset: IM |
Affiliation:
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School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation* Adaptation, Physiological / physiology* Algorithms Animals Chinchilla Cochlear Nerve / physiopathology* Hearing Loss, Noise-Induced / physiopathology* Male Models, Animal Nerve Fibers / physiology Reaction Time / physiology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 DC009838-01A1/DC/NIDCD NIH HHS; R01 DC009838-03/DC/NIDCD NIH HHS; R01DC009838/DC/NIDCD NIH HHS; R03 DC007348-04/DC/NIDCD NIH HHS; R03DC07348/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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