Document Detail


Noise-induced cochlear hypoxia is intensity dependent, correlates with hearing loss and precedes reduction of cochlear blood flow.
MedLine Citation:
PMID:  9390798     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anesthetized and artificially ventilated guinea pigs were exposed to broad-band noise of 95, 101, 106 or 115 dB SPL for 30 min and studied for 180 min after cessation of noise. The partial pressure of oxygen (pO2) in the perilymph, the cochlear blood flow (CoBF) and auditory-evoked potentials were continuously recorded. Arterial blood pressure, electrocardiogram, inspiratory and expiratory gas levels, arterial blood gas levels and acid-base status were kept stable to exclude influences of these parameters on cochlear parameters. Exposure to 95 dB SPL did not affect perilymphatic pO2 or CoBF. Cochlear microphonics (CMs) were reduced, but compound action potentials of the auditory nerve (CAPs) and auditory brainstem potentials (ABRs) increased after exposure to this low-level noise. Perilymphatic pO2 decreased during exposure to 101 dB SPL and then further decreased during the subsequent 60 min after cessation of the noise. CoBF did not change significantly during and 30 min after noise but then paralleled the decline of perilymphatic pO2. However, both parameters showed a clear indication of recovery in the second and third hours after noise. At 101 dB SPL, CMs were again reduced immediately, CAPs were unaltered and ABRs again increased. Exposure to 106 and to 115 dB SPL resulted in a decrease in both perilymphatic pO2 and CoBF; this decrease began during the exposure but became progressively worse after the noise. Hearing loss was observed immediately with exposure and showed no signs of further deterioration after cessation. The observed time courses of changes are important. They reveal that hearing loss and cochlear hypoxia precede reduction in CoBF due to noise exposure. The potential mechanisms underlying these effects are discussed.
Authors:
K Lamm; W Arnold
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Audiology & neuro-otology     Volume:  1     ISSN:  1420-3030     ISO Abbreviation:  Audiol. Neurootol.     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1997-12-31     Completed Date:  1997-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9606930     Medline TA:  Audiol Neurootol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  148-60     Citation Subset:  IM    
Affiliation:
Clinic for Otolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Fatigue / physiology
Blood Flow Velocity / physiology
Brain Stem / physiopathology
Cell Hypoxia / physiology*
Cochlea / blood supply*
Evoked Potentials, Auditory, Brain Stem / physiology
Female
Guinea Pigs
Hearing Loss, Noise-Induced / physiopathology*
Ischemia / physiopathology*
Loudness Perception / physiology*
Male
Noise / adverse effects*
Oxygen / blood
Rheology
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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