| Noise generation, amplification and propagation in chemotactic signaling systems of living cells. | |
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MedLine Citation:
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PMID: 18501501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Theoretical considerations of stochastic signal transduction in living cells have revealed the gain-fluctuation relation, which provides a theoretical framework to describe quantitatively how noise is generated, amplified and propagated along a signaling cascade in living cells. We chose the chemotactic signaling of bacteria and eukaryotic cells as a typical example of noisy signal transduction and applied the gain-fluctuation relation to these signaling systems in order to analyze the effects of noise on signal transduction. Comparing our theoretical analysis with the experimental results of chemotaxis in bacteria Escherichia coli and eukaryote Dictyostelium discoideum revealed that noise in signal transduction systems limits the cells' chemotactic ability and contributes to their behavioral variability. Based on the kinetic properties of signaling molecules in living cells, the gain-fluctuation relation can quantitatively explain stochastic cellular behaviors. |
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Authors:
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Tatsuo Shibata; Masahiro Ueda |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-22 |
Journal Detail:
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Title: Bio Systems Volume: 93 ISSN: 0303-2647 ISO Abbreviation: BioSystems Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-07-18 Completed Date: 2008-09-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0430773 Medline TA: Biosystems Country: Ireland |
Other Details:
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Languages: eng Pagination: 126-32 Citation Subset: IM |
Affiliation:
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Department of Mathematical and Life Sciences, University of Hiroshima, Higashi-Hiroshima, Hiroshima 739-8526, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Survival Chemotaxis* Dictyostelium / cytology, metabolism Ligands |
| Chemical | |
Reg. No./Substance:
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0/Ligands |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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