| Nodular spindle cell proliferation in the wall of a varicose vein mimicking Kaposi's sarcoma. | |
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MedLine Citation:
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PMID: 20412343 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Exuberant reparative reactions resembling sarcoma have been reported in the genitourinary tract, thyroid, breast, lymph node, oral cavity and skin, but not in a varicose vein. Presented herein is the case of a 55-year-old man who showed an incidental nodular lesion in the wall of a varicose vein on the left leg. The nodule consisted of fascicles of spindled cells with ovoid or elongated nuclei and delicate chromatin that showed diffuse reactivity for CD31, alpha-smooth muscle actin and D2-40. This histopathological appearance, when coupled with extravasated erythrocytes and interstitial hemosiderin deposits, resembled Kaposi's sarcoma or spindle cell angiosarcoma. Key features helpful for recognizing that the proliferation we describe is a form of tissue repair include an association with obvious hemorrhage; lack of well-formed curved fascicles of spindled cells; lack of intracytoplasmic hyaline globules; lack of intracellular vacuolization; cytological blandness; low mitotic count; absence of inmmunoreactivity for human herpesvirus-8 (HHV-8) latent nuclear antigen-1; and absence of HHV-8 in polymerase chain reaction (PCR) analysis. Val-Bernal JF, Val D, Garijo MF, Gómez-Román JJ. Nodular spindle cell proliferation in the wall of a varicose vein mimicking Kaposi's sarcoma. |
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Authors:
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José Fernando Val-Bernal; Daniel Val; María Francisca Garijo; José Javier Gómez-Román |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cutaneous pathology Volume: 38 ISSN: 1600-0560 ISO Abbreviation: J. Cutan. Pathol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425124 Medline TA: J Cutan Pathol Country: Denmark |
Other Details:
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Languages: eng Pagination: 376-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 John Wiley & Sons A/S. |
Affiliation:
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Anatomical Pathology Department, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain Anatomical Pathology Service, Carlos III Hospital, Madrid, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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