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Nodular secondary syphilis with associated granulomatous inflammation: Case report and literature review.
MedLine Citation:
PMID:  24447075     Owner:  NLM     Status:  Publisher    
A 62-year-old male presented with a 10-day history of a diffuse, erythematous papular rash sparing the palms and soles. Histopathologic examination of a skin lesion demonstrated loose non-caseating granulomas in a lymphoplasmacytic background. Scattered spirochetes were identified by T. pallidum immunohistochemistry, in keeping with a diagnosis of secondary syphilis. Granulomatous inflammation in secondary syphilis is uncommon. A review of the literature reveals that the majority of prior reported cases of granulomatous secondary syphilis share similar characteristics to the presented case; namely, a papular or nodular clinical presentation, sparing of the palms and soles, and collections of epithelioid histiocytes with associated lymphocytes and variable numbers of plasma cells.
Carolyn Rysgaard; Erik Alexander; Brian L Swick
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-22
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  -     ISSN:  1600-0560     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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This article is protected by copyright. All rights reserved.
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