Document Detail

Nodular sclerosing Hodgkin's disease with giant Reed-Sternberg cells.
MedLine Citation:
PMID:  3279534     Owner:  NLM     Status:  MEDLINE    
A 70-year-old woman with multiple symptoms and extensive lymphadenopathy had a lymph node biopsy specimen that contained highly pleomorphic, giant Reed-Sternberg cells that resembled cells from other malignant giant cell neoplasms. The cells were strongly positive for Leu-M1, alpha 1-antitrypsin, S-100 protein, kappa light chain, and lambda light chain. With five courses of chemotherapy for pathologic stage IV-B Hodgkin's disease, the patient achieved a complete remission, and remains free of disease 85 months after diagnosis.
H F Frierson; D J Innes; C E Hess
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  81     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-21     Completed Date:  1988-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-4     Citation Subset:  AIM; IM    
Department of Pathology, University of Virginia Medical Center, Charlottesville 22908.
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MeSH Terms
Bone Marrow Examination
Bone Neoplasms / drug therapy,  pathology
Diagnosis, Differential
Giant Cell Tumors / pathology
Histiocytes / pathology*
Hodgkin Disease / drug therapy,  pathology*
Lymph Nodes / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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