Document Detail

Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension.
MedLine Citation:
PMID:  21472097     Owner:  NLM     Status:  MEDLINE    
Nodular regenerative hyperplasia (NRH) is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules. NRH may lead to the development of non-cirrhotic portal hypertension. There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series. NRH may develop via autoimmune, hematological, infectious, neoplastic, or drug-related causes. The disease is usually asymptomatic, slowly or non-progressive unless complications of portal hypertension develop. Accurate diagnosis is made by histopathology, which demonstrates diffuse micronodular transformation without fibrous septa. Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver. While the initial treatment is to address the underlying disease, ultimately the therapy is directed to the management of portal hypertension. The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension. In this review we detail the epidemiology, pathogenesis, diagnosis, management, and prognosis of NRH.
Marek Hartleb; Krzysztof Gutkowski; Piotr Milkiewicz
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-07-25     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1400-9     Citation Subset:  IM    
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MeSH Terms
Focal Nodular Hyperplasia / complications,  diagnosis*,  epidemiology,  therapy
Hypertension, Portal / etiology*,  physiopathology
Liver / pathology*
Liver Regeneration*
Portal Pressure
Predictive Value of Tests
Risk Assessment
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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