| Nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT. | |
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MedLine Citation:
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PMID: 8683307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The uptake of L-1-[11C]-tyrosine (TYR) in cervical lymph nodes of eleven patients with squamous-cell carcinoma (SCC) of the oral cavity was studied with PET to detect lymphogenic metastases. METHODS: The TYR-PET results were compared with clinical, MRI, CT, histopathologic findings and historical data of patients studied with FDG. Sensitivity, specificity, accuracy and the positive and negative predictive values were calculated. RESULTS: TYR-PET had sensitivity of 83% and a specificity of 95%. In contrast, the sensitivity and specificity for MRI were 33% and 96%, respectively. The sensitivity and specificity for CT were 55% and 91%, respectively. TYR-PET results compared favorably with FDG. CONCLUSION: With TYR-PET, SCC metastases of the oral cavity can be visualized with high sensitivity and specificity. TYR-PET can be an additional tool for further evaluation of neck malignancies. |
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Authors:
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J W Braams; J Pruim; P G Nikkels; J L Roodenburg; W Vaalburg; A Vermey |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 37 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-08-22 Completed Date: 1996-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 897-901 Citation Subset: IM |
Affiliation:
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Department of Oral and Maxillofacial Surgery, Groningen University Hospital, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carbon Radioisotopes / diagnostic use* Carcinoma, Squamous Cell / diagnosis, radiography, radionuclide imaging, secondary* Female Humans Lymph Nodes / pathology, radiography, radionuclide imaging Lymphatic Metastasis / diagnosis, radiography, radionuclide imaging Magnetic Resonance Imaging* Male Middle Aged Mouth Neoplasms / pathology* Predictive Value of Tests Sensitivity and Specificity Tomography, Emission-Computed* Tomography, X-Ray Computed* Tyrosine / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 55520-40-6/Tyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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