Document Detail

Nocturnal subcutaneous apomorphine infusion in Parkinson's disease and restless legs syndrome.
MedLine Citation:
PMID:  10478579     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Nocturnal disabilities leading to fragmented sleep arising from parkinsonian off period related complications are common, under-reported and are difficult to treat. In this study, we evaluate the use of nocturnal continuous subcutaneous overnight apomorphine infusion in Parkinson's disease and restless legs syndrome. METHODS: Six parkinsonian patients and 2 patients with restless legs syndrome with nocturnal disabilities refractory to conventional oral therapy were assessed using a sleep diary while on standard treatment and during nocturnal apomorphine infusion. Three patients agreed to assessments during placebo infusion with normal saline. RESULTS: Apomorphine led to a dramatic reduction of nocturnal awakenings, nocturnal off periods, pain, dystonia and nocturia in parkinsonian patients. In patients with restless legs syndrome, apomorphine reduced nocturnal discomfort, reduced leg movements and improved pain and spasm scores significantly. Placebo infusion reproduced pain, nocturnal spasms and sleep disruption. CONCLUSION: This study suggests that overnight apomorphine infusion may be effective in overcoming refractory nocturnal disabilities in selected patients with Parkinson's disease and restless legs syndrome.
I Reuter; C M Ellis; K Ray Chaudhuri
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  100     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-20     Completed Date:  1999-10-20     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  163-7     Citation Subset:  IM    
Autonomic and Movement Disorder Unit, Regional Neuroscience Centre, King's College Hospital, London, UK.
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MeSH Terms
Antiparkinson Agents / administration & dosage*,  adverse effects
Apomorphine / administration & dosage*,  adverse effects
Drug Administration Schedule
Follow-Up Studies
Injections, Subcutaneous
Levodopa / administration & dosage
Middle Aged
Parkinson Disease / drug therapy*
Restless Legs Syndrome / drug therapy*
Sleep Disorders / drug therapy
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; 58-00-4/Apomorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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