Document Detail

Nocturnal and respiratory disturbances in Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy).
MedLine Citation:
PMID:  8761503     Owner:  NLM     Status:  MEDLINE    
Respiratory and sleep disturbances may be important causes of morbidity in Steele-Richardson-Olszewski syndrome but the frequency and character of nocturnal abnormalities remains uncertain. A prospective study of 11 patients with Steele-Richardson-Olszewski syndrome and age-matched control subjects was undertaken using clinical assessments, a structured sleep questionnaire, spirometry, static maximum inspiratory and expiratory pressures and nocturnal oximetry. The mean age of the Steele-Richardson-Olszewski syndrome patients was 63.2 (52-70) years and mean disease duration was 4.0 (2-6) years. There was moderate to severe motor disability in nine and mild to moderate dementia in eight. In the patients with Steele-Richardson-Olszewski syndrome the following abnormalities contributed to sleep disturbances significantly more frequently than in normal controls: depression, dysphagia, frequent nocturnal awakenings (usually associated with urinary frequency), immobility in bed, difficulty with transfers, impaired dressing and feeding. There was profound impairment of voluntary respiratory control whilst automatic and limbic control were well maintained. Nocturnal respiratory abnormalities were not present even in the most severely disabled. In Steele-Richardson-Olszewski syndrome sleep abnormalities are common; they relate to the cognitive, pseudobulbar and extrapyramidal disturbances and may therefore be amenable to symptomatic control.
V S De Bruin; C Machado; R S Howard; N P Hirsch; A J Lees
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  72     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-10-28     Completed Date:  1996-10-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  293-6     Citation Subset:  IM    
Harris/Batten Unit, National Hospital for Neurology and Neurosurgery, London, UK.
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MeSH Terms
Case-Control Studies
Middle Aged
Prospective Studies
Respiration Disorders / etiology*
Respiratory Function Tests
Sleep Disorders / etiology*
Supranuclear Palsy, Progressive / complications*,  pathology,  physiopathology

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