Document Detail

Nocturnal mechanical ventilation improves exercise capacity in kyphoscoliotic patients with respiratory impairment.
MedLine Citation:
PMID:  15148837     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Patients with severe kyphoscoliosis, with or without stable respiratory failure, frequently experience oxyhaemoglobin desaturation during sleep, exercise, or both. Nasal Intermittent Positive Pressure Ventilation (NIPPV) applied during sleep has been demonstrated to be able to control nocturnal desaturations and also improve diurnal respiratory failure, if this is present, in this group of patients. The aim of this study was to evaluate the effect of a seven-day treatment with nocturnal NIPPV on exercise tolerance in a group of 6 patients with severe kyphoscoliosis and significant nocturnal and exercise-induced oxyhaemoglobin desaturation. METHODS: NIPPV was applied each night for a week by means of a volume cycled pressure ventilator set in assisted/controlled mode. In each patient lung function, daytime arterial blood gas analysis, overnight non invasive recording of arterial saturation, and 6-minutes walking test were carried out initially and at the end of the NIPPV course. RESULTS: During nocturnal NIPPV, as compared to baseline, the percent of night time spent below 90% of oxyhaemoglobin saturation significantly fell from 20 +/- 12.8 to 2.3 +/- 1.9 (Student t-test: p = 0.017). The 6-minute walking distance significantly increased from 244.7 +/- 132.2 to 340 +/- 122.3 m (p = 0.0097). Spirometry, daytime arterial blood gas analysis, and exercise-induced oxyhaemoglobin desaturation were unaffected by treatment. CONCLUSION: A one-week course of treatment with nocturnal NIPPV improves exercise capacity in patients with severe kyphoscoliosis.
S Fuschillo; A De Felice; C Gaudiosi; G Balzano
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  59     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:    2003 Oct-Dec
Date Detail:
Created Date:  2004-05-19     Completed Date:  2004-06-15     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  281-6     Citation Subset:  IM    
Division of Pneumology, Salvatore Maugeri Foundation IRCCS, Scientific Institute of Telese Terme (BN), Via Bagni Vecchi 1, 82037 Telese Terme, BN, Italy.
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MeSH Terms
Blood Gas Analysis
Exercise Tolerance / physiology*
Follow-Up Studies
Intermittent Positive-Pressure Ventilation / methods*
Kyphosis / complications,  therapy*
Middle Aged
Pulmonary Gas Exchange
Respiratory Function Tests
Sampling Studies
Scoliosis / complications,  therapy*
Severity of Illness Index
Treatment Outcome
Vital Capacity
Comment On:
Monaldi Arch Chest Dis. 2003 Oct-Dec;59(4):267-8   [PMID:  15148834 ]

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