Document Detail

Nocturnal hypoxemia: a neglected cardiovascular risk factor in end-stage renal disease?
MedLine Citation:
PMID:  11803169     Owner:  NLM     Status:  MEDLINE    
Its is well established that sleep apnea (SA) is a health problem of paramount importance because it disrupts sleep and quality of life and may induce serious neuroendocrine and cardiovascular complications. There is little doubt that chronic renal failure is an independent cause of SA. The hypothesis that SA may depend on the accumulation of endogenous opioids still remains to be tested. Cytokines, particularly TNF-alpha and IL-6 which are much elevated in end-stage renal disease (ESRD), may also be implicated in the pathogenesis of SA. Nocturnal hypoxemia is an independent predictor of cardiovascular events in ESRD and the prediction power of this parameter remains strong and substantially unmodified after statistical adjustment for established cardiovascular risk factors in the dialysis population. Left ventricular hypertrophy and dysautonomia appear to be most likely intermediate mechanisms mediating the adverse cardiovascular effects of SA in ESRD.
Carmine Zoccali; Francesca Mallamaci; Giovanni Tripepi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood purification     Volume:  20     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  2002  
Date Detail:
Created Date:  2002-01-22     Completed Date:  2003-04-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
CNR Centro Fisiologia Clinica, Reggio Calabria, Italy.
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MeSH Terms
Anoxia / complications,  etiology*
Autonomic Nervous System Diseases / etiology
Cardiovascular Diseases / etiology,  mortality
Hypertrophy, Left Ventricular / etiology
Kidney Failure, Chronic / complications*,  mortality
Positive-Pressure Respiration
Proportional Hazards Models
Risk Factors
Sleep Apnea Syndromes / complications,  etiology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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