| Nocturnal evolution of respiratory effort in obstructive sleep apnoea syndrome: influence on arousal threshold. | |
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MedLine Citation:
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PMID: 9877474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been recently described that the overnight increase in maximal end-apnoeic oesophageal pressure (P(oes,max)), considered as an index of the arousal threshold to occlusion, mostly contributes to apnoea lengthening during the night. However, the rise in apnoea duration could also be caused by changes in hypoxaemia, chemosensitivity and upper airway resistance. To better define the relative contributions of each of these factors, we examined the recordings of nine patients. Before apnoea, the mean pulmonary resistance at peak inspiratory flow (RPIF) was computed. During apnoea, all swings in oesophageal pressure (P(oes)) were measured to define the P(oes,max), the increase from the minimum to the maximum (deltaP(oes)), the rate of increase in P(oes) (RP(oes)) and the P(oes) at the first occluded breath (P(oes,1)). A gradual and significant increase in apnoea duration (p=0.02), P(oes,max) (p=0.02) and deltaP(oes) (p=0.006) was present across the night without any changes in oxygen saturation, RPIF, and P(oes,1). The slope of increase in P(oes,max), apnoea duration and deltaP(oes) was correlated with the apnoea/hypopnoea index. We conclude that in obstructive sleep apnoea, the nocturnal rise in apnoea duration is attributable more to an increase in the arousal threshold related to apnoea recurrence than to changes in chemosensitivity and upper airway resistance. |
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Authors:
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E Sforza; J Krieger; C Petiau |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 12 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-03-04 Completed Date: 1999-03-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 1257-63 Citation Subset: IM |
Affiliation:
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Sleep Disorders Unit, University Hospital, Strasbourg, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Resistance Arousal* Esophagus / physiopathology Humans Male Middle Aged Polysomnography Pressure Respiration* Sleep Apnea Syndromes / physiopathology* Sleep Stages* Work of Breathing |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 1998 Dec;12(6):1239-41
[PMID:
9877469
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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