| Nocturnal dip in the optic nerve head perfusion. | |
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MedLine Citation:
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PMID: 10715378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Many physiological parameters, including blood pressure, show circadian variations. Diurnal fluctuations of the optic nerve head (ONH) circulation have not yet been studied. The purpose of the present study was to determine the pattern of ONH blood flow variations over a 24-hour period in healthy subjects. METHODS: The subject group comprised 15 healthy volunteers (6 women, 9 men) aged 22 to 43 years (mean +/- SEM: 28.2 +/- 1.3 years). Blood flow in the ONH was measured by laser Doppler flowmetry (LDF) over a 24-hour period at 08:00, 12:00, 16:00, 20:00, 24:00 hours, and at 08:00 hours the following morning. RESULTS: ONH perfusion varied significantly over time. The mean LDF-flow during daytime ranged from 8.2 to 8.9 arbitrary units (AU) and fell at midnight to 7.1 AU (P =.0015). The mean LDF-volume during daytime was 0.23 to 0.24 AU and decreased at midnight to 0.20 AU (P =.04). The mean LDF-velocity ranged from 0.39 to 0.41 kHz with no significant differences at any time point. CONCLUSIONS: Our study in normal subjects reveals small mean changes of ONH perfusion during daytime and a significant reduction at night. The physiological and clinical relevance of the nocturnal dip in the ONH perfusion needs to be determined in future studies. |
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Authors:
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R Osusky; P Rohr; A Schötzau; J Flammer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese journal of ophthalmology Volume: 44 ISSN: 0021-5155 ISO Abbreviation: Jpn. J. Ophthalmol. Publication Date: 2000 Mar-Apr |
Date Detail:
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Created Date: 2000-06-06 Completed Date: 2000-06-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0044652 Medline TA: Jpn J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 128-31 Citation Subset: IM |
Affiliation:
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University Eye Hospital, Basel, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Circadian Rhythm* Female Humans Laser-Doppler Flowmetry Male Optic Disk / blood supply* Reference Values Regional Blood Flow |
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