| Nocturnal continuous positive airway pressure decreases daytime sympathetic traffic in obstructive sleep apnea. | |
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MedLine Citation:
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PMID: 10587337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with obstructive sleep apnea (OSA) have high levels of muscle sympathetic nerve activity (MSNA). We tested the hypothesis that long-term continuous positive airway pressure (CPAP) treatment will decrease MSNA in OSA patients. METHODS AND RESULTS: We measured blood pressure, heart rate, and MSNA in 11 normotensive, otherwise healthy patients with OSA who were treated with CPAP. The measurements were obtained at baseline and after 1 month, 6 months, and 1 year of CPAP treatment. These measurements were compared with those recorded in 9 otherwise healthy OSA patients who were not treated with CPAP for 1 year. In both untreated and treated patients, blood pressure and heart rate did not change over time. MSNA was similar during repeated measurements in the untreated group. By contrast, MSNA decreased significantly over time in patients treated with CPAP. This decrease was evident after both 6 months and 1 year of CPAP treatment (P=0.02 for both). CONCLUSIONS: CPAP treatment decreases muscle sympathetic traffic in patients with OSA. This effect of CPAP is evident only after an extended duration of therapy. |
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Authors:
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K Narkiewicz; M Kato; B G Phillips; C A Pesek; D E Davison; V K Somers |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 100 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1999 Dec |
Date Detail:
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Created Date: 1999-12-29 Completed Date: 1999-12-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2332-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University of Iowa, Iowa City, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Airway Obstruction / physiopathology, therapy Blood Pressure Electrophysiology Female Heart Rate Humans Male Middle Aged Night Care / methods Positive-Pressure Respiration* Sleep Apnea Syndromes / physiopathology*, therapy* Sympathetic Nervous System / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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3F05 TW05200/TW/FIC NIH HHS; HL14388/HL/NHLBI NIH HHS; HL61560/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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