Document Detail

Nocturnal blood pressure and silent cerebrovascular lesions in elderly Japanese.
MedLine Citation:
PMID:  8711795     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: We conducted a cross-sectional epidemiological survey using ambulatory blood pressure monitoring and brain MRI in a cohort from northern Japan to determine whether an inappropriately low nocturnal blood pressure, or an excess fall in nocturnal blood pressure, might be responsible for silent cerebrovascular lesions in the elderly. METHODS: Untreated subjects over 55 years and under 64 years of age (late middle age; 24 men and 46 women, 60% of eligible people) and over 65 years and under 75 years of age (elderly; 29 men and 52 women, 91% of eligible people) participated in the study. We evaluated the relationship between the amplitude (Daytime Average-Nighttime Average) or the rate ([Daytime Average-Nighttime Average]/Daytime Average) of the fall in nocturnal blood pressure and the incidence of silent cerebrovascular lesions on MRI (number of lacunar infarctions or extent of periventricular hyperintensity). RESULTS: The amplitude or the rate of the fall in nocturnal blood pressure in elderly women with one or two lacunar infarctions was significantly higher than that in those without such infarctions. There was a significant positive correlation between the amplitude or the rate of the fall in nocturnal blood pressure and the extent of periventricular hyperintensity in the elderly women. This relationship was observed in women, but not in men, of late middle age; this was not seen in elderly men. CONCLUSIONS: Results indicate that an inappropriately low nocturnal blood pressure, or an excessive fall in nocturnal blood pressure, is associated with ischemic silent cerebrovascular lesions, at least in elderly women. Treatment of hypertension in such women should be administered with care and with regard to nocturnal blood pressure.
N Watanabe; Y Imai; K Nagai; I Tsuji; H Satoh; M Sakuma; H Sakuma; J Kato; N Onodera-Kikuchi; M Yamada; F Abe; S Hisamichi; K Abe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  27     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-09-10     Completed Date:  1996-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1319-27     Citation Subset:  IM    
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Age Distribution
Blood Pressure / physiology*
Brain Ischemia / diagnosis,  epidemiology,  physiopathology
Cerebral Infarction / diagnosis,  epidemiology,  physiopathology
Cerebrovascular Disorders / diagnosis,  epidemiology*,  physiopathology
Circadian Rhythm / physiology*
Cohort Studies
Cross-Sectional Studies
Hypertension / complications,  epidemiology
Japan / epidemiology
Magnetic Resonance Imaging
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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