Document Detail

Nocturnal blood pressure but not insulin resistance influences endothelial function in treated hypertensive patients.
MedLine Citation:
PMID:  20237501     Owner:  NLM     Status:  In-Data-Review    
The impact of insulin sensitivity, casual blood pressure and 24-h ambulatory blood pressure on endothelial function was studied in treated hypertensive subjects. Flow-mediated dilatation of the brachial artery after reperfusion was used to determine endothelial function. Insulin sensitivity indices were obtained by using the homeostasis model assessment, after 75 g Dextrose oral glucose tolerance tests (Matsuda index) and the euglycemic hyperinsulinemic clamp (M-value) in 49 patients with arterial hypertension. The insulin sensitivity indices were compared with healthy controls matched for body weight, age and sex (n=23). Hypertensive patients under therapy were insulin resistant, had higher LDL-cholesterol levels, higher blood pressure and lower endothelial function than healthy controls. Flow-mediated dilatation showed, in the study population being treated for arterial hypertension, no relationships of all insulin sensitivity indices with flow-mediated dilatation, casual blood pressure in the morning before the tests and 24-h ambulatory blood pressure. Flow-mediated dilatation was strongly influenced by nocturnal systolic and diastolic 24-h ambulatory blood pressure (systolic: R(2)=0.0943, P<0.05; diastolic: R(2)=0.0947, P<0.05). Therefore, endothelial function in these patients is predominantly influenced by nocturnal systolic and diastolic blood pressure and not by insulin sensitivity.
T Konrad; S Franke; F Schneider; F Bär; G Vetter; K Winkler
Publication Detail:
Type:  Journal Article     Date:  2010-03-18
Journal Detail:
Title:  Journal of human hypertension     Volume:  25     ISSN:  1476-5527     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  18-24     Citation Subset:  IM    
Institute for Metabolic Research, Academic Institute of the Medical Faculty of Goethe-University Frankfurt am Main, German Study Centre for the EU-RISC-Study: Relationship between Insulin Sensitivity and Cardiovascular Risk (QLRT-CT-2001-01252), Frankfurt am Main, Germany.
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