| Nocturnal intermittent serious hypoxia and reoxygenation in proliferative diabetic retinopathy cases. | |
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MedLine Citation:
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PMID: 20381785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To clarify the relationship between evaluation items of sleep-disordered breathing and diabetic retinopathy in detail. DESIGN: Cross-sectional comparative study. METHODS: Sixty-eight consecutive nonproliferative diabetic retinopathy and 151 proliferative diabetic retinopathy (PDR) cases who had undergone surgeries in our department were included in this study. Pulse oximetry was conducted overnight and mean oxygen saturation by pulse oximeter (SpO(2); %), the sleeping 4% oxygen desaturation index (4% ODI times/hour), lowest SpO(2) (%), and the cumulative percent time spent at SpO(2) < 90% (CT 90%) were calculated. The results were evaluated and compared between the 2 groups. In addition, these results and preoperative patient background factors were analyzed using logistic regression analysis to clarify risk factor of PDR. RESULTS: 4% ODI and CT 90% in the PDR group were significantly higher than in the nonproliferative diabetic retinopathy group (4% ODI, 7.8 vs. 4.9; P = .007; CT 90%, 2.2 vs 0.8; P = .0006). Lowest SpO(2) was significantly lower in the PDR group than in the nonproliferative diabetic retinopathy groups (82.4 vs 87.0; P = .0006). Logistic regression analysis identified being younger, having a lower value for the lowest SpO(2), and a high hemoglobin A1c value to be risk factors for PDR (age: odds ratio, 0.90; 95% confidence interval, -0.86 to -0.94; P < .0001; lowest SpO(2): odds ratio, 0.93; 95% confidence interval, 0.88 to 0.99; P = .02; hemoglobin A1c: odds ratio, 1.00 to 1.69; P = .047). CONCLUSIONS: This study indicated that PDR cases had episodes of nocturnal intermittent hypoxia and reoxygenation as a result of sleep-disordered breathing and that low-value lowest SpO(2) were the risk factors for PDR development. |
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Authors:
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Tomoaki Shiba; Takatoshi Maeno; Yoshitsugu Saishin; Yuichi Hori; Mao Takahashi |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-04-09 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 149 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 959-63 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Ophthalmology, Toho University Sakura Medical Center, Sakura, Chiba, Japan. tomoaki-s@sakura.med.toho-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anoxia / diagnosis, metabolism, physiopathology* Cross-Sectional Studies Diabetes Mellitus, Type 2 / complications Diabetic Retinopathy / diagnosis, metabolism, physiopathology* Female Hemoglobin A, Glycosylated / analysis Humans Male Middle Aged Oximetry Oxygen / metabolism* Oxygen Consumption Risk Factors Sleep Sleep Apnea Syndromes / diagnosis, metabolism, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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