| Nocturnal gastroesophageal reflux revisited by impedance-pH monitoring. | |
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MedLine Citation:
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PMID: 21602991 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Impedance-pH monitoring allows detailed characterization of gastroesophageal reflux and esophageal activity associated with reflux. We assessed the characteristics of nocturnal reflux and esophageal activity preceding and following reflux. METHODS: Impedance-pH tracings from 11 healthy subjects and 76 patients with gastroesophageal reflux disease off acid-suppressive therapy were analyzed. Characteristics of nocturnal supine reflux, time distribution and esophageal activity seen on impedance at 2 minute intervals preceding and following reflux were described. RESULTS: Patients had more nocturnal reflux events than healthy subjects (8 [4-12] vs 2 [1-5], P = 0.002), with lower proportion of weakly acidic reflux (57% [35-78] vs 80% [60-100], P = 0.044). Nocturnal reflux was mainly liquid (80%) and reached the proximal esophagus more often in patients (6% vs 0%, P = 0.047). Acid reflux predominated in the first 2 hours (66%) and weakly acidic reflux in the last 3 hours (70%) of the night. Most nocturnal reflux was preceded by aboral flows and cleared by short lasting volume clearance. In patients, prolonged chemical clearance was associated with less esophageal activity. CONCLUSIONS: Nocturnal weakly acidic reflux is as common as acid reflux in patients with gastroesophageal reflux disease, and predominates later in the night. Impedance-pH can predict prolonged chemical clearance after nocturnal acid reflux. |
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Authors:
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Fernando Fornari; Kathleen Blondeau; Veerle Mertens; Jan Tack; Daniel Sifrim |
Publication Detail:
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Type: Journal Article Date: 2011-04-27 |
Journal Detail:
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Title: Journal of neurogastroenterology and motility Volume: 17 ISSN: 2093-0887 ISO Abbreviation: J Neurogastroenterol Motil Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-05-23 Completed Date: 2011-06-16 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101530189 Medline TA: J Neurogastroenterol Motil Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 148-57 Citation Subset: - |
Affiliation:
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Center for Gastroenterological Research, Catholic University of Leuven, Belgium. FernandoFornari@gmail.com |
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