Document Detail

Nocturnal gastroesophageal reflux revisited by impedance-pH monitoring.
MedLine Citation:
PMID:  21602991     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND/AIMS: Impedance-pH monitoring allows detailed characterization of gastroesophageal reflux and esophageal activity associated with reflux. We assessed the characteristics of nocturnal reflux and esophageal activity preceding and following reflux.
METHODS: Impedance-pH tracings from 11 healthy subjects and 76 patients with gastroesophageal reflux disease off acid-suppressive therapy were analyzed. Characteristics of nocturnal supine reflux, time distribution and esophageal activity seen on impedance at 2 minute intervals preceding and following reflux were described.
RESULTS: Patients had more nocturnal reflux events than healthy subjects (8 [4-12] vs 2 [1-5], P = 0.002), with lower proportion of weakly acidic reflux (57% [35-78] vs 80% [60-100], P = 0.044). Nocturnal reflux was mainly liquid (80%) and reached the proximal esophagus more often in patients (6% vs 0%, P = 0.047). Acid reflux predominated in the first 2 hours (66%) and weakly acidic reflux in the last 3 hours (70%) of the night. Most nocturnal reflux was preceded by aboral flows and cleared by short lasting volume clearance. In patients, prolonged chemical clearance was associated with less esophageal activity.
CONCLUSIONS: Nocturnal weakly acidic reflux is as common as acid reflux in patients with gastroesophageal reflux disease, and predominates later in the night. Impedance-pH can predict prolonged chemical clearance after nocturnal acid reflux.
Fernando Fornari; Kathleen Blondeau; Veerle Mertens; Jan Tack; Daniel Sifrim
Publication Detail:
Type:  Journal Article     Date:  2011-04-27
Journal Detail:
Title:  Journal of neurogastroenterology and motility     Volume:  17     ISSN:  2093-0887     ISO Abbreviation:  J Neurogastroenterol Motil     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-05-23     Completed Date:  2011-06-16     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101530189     Medline TA:  J Neurogastroenterol Motil     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  148-57     Citation Subset:  -    
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Grant Support
G0802313//Medical Research Council

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