| Nocturnal blood glucose and IGFBP-1 changes in type 1 diabetes: Differences in the dawn phenomenon between insulin regimens. | |
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MedLine Citation:
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PMID: 19834874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Insulin-like growth factor binding protein-1 (IGFBP-1) is known to regulate the bioavailability of insulin-like growth factor (IGF) and the levels of IGFBP-1 are increased in the morning in patients with type 1 diabetes mellitus. We investigated the nocturnal fluctuations of glucose, IGFBP-1, and free IGF-1 levels with three insulin regimens. RESEARCH DESIGN AND METHODS: Forty-eight type 1 diabetes patients were divided into three groups according to their basal insulin therapy (continuous subcutaneous insulin infusion [CSII], insulin glargine, NPH insulin). Blood samples were obtained every 2 h between 2 300 h and 0700 h to measure plasma glucose, IGFBP-1 and free IGF-1 levels. RESULTS: The dawn phenomenon was more frequent with NPH (62.1%) than with glargine (16.6%, p<0.05) and CSII (14.3%, p<0.05). In the NPH group, the serum IGFBP-1 levels were markedly increased from 21.0+/-3.6 ng/ml at 2 300 h to 200.3+/-21.8 ng/ml at 0700 h and free IGF-1 levels were inversely decreased; these changes were partially suppressed in the CSII and glargine groups. CONCLUSIONS: The use of insulin regimens that provide sufficient insulin levels in the early morning can suppress the dawn phenomenon, leading to improved glycemic control. The increase in circulating IGFBP-1 in the morning, as a result of waning of insulin action, lowers free IGF-1 levels and may cause insulin resistance. |
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Authors:
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H Yagasaki; K Kobayashi; T Saitou; K Nagamine; Y Mitsui; M Mochizuki; K Kobayashi; H Cho; K Ohyama; S Amemiya; S Nakazawa |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-10-15 |
Journal Detail:
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Title: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association Volume: 118 ISSN: 1439-3646 ISO Abbreviation: Exp. Clin. Endocrinol. Diabetes Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505926 Medline TA: Exp Clin Endocrinol Diabetes Country: Germany |
Other Details:
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Languages: eng Pagination: 195-9 Citation Subset: IM |
Copyright Information:
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J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart * New York. |
Affiliation:
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Department of Pediatrics, University of Yamanashi, Japan. yagasaki@mwd.biglobe.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Blood Glucose / analysis, metabolism* Circadian Rhythm / physiology Diabetes Mellitus, Type 1 / blood, drug therapy*, metabolism Female Humans Insulin / administration & dosage*, analogs & derivatives*, therapeutic use Insulin Infusion Systems Insulin, NPH / administration & dosage*, therapeutic use Insulin-Like Growth Factor Binding Protein 1 / blood, metabolism* Insulin-Like Growth Factor I / analysis Male |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Insulin-Like Growth Factor Binding Protein 1; 0/glargine; 11061-68-0/Insulin; 53027-39-7/Insulin, NPH; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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