Document Detail


Nocturia is associated with an increased risk of coronary heart disease and death.
MedLine Citation:
PMID:  22233166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether nocturia is associated with the development of diabetes mellitus, hypertension, coronary heart disease (CHD) and occurrence of death.
MATERIALS AND METHODS: We studied data obtained from a retrospective cohort of randomly selected men, aged 40-79 years in 1990, from Olmsted County, MN, USA. Moderate nocturia was defined as waking to urinate ≥2 times per night. Men were followed every 2 years through repeated questionnaires and community medical records to assess development of diabetes mellitus and hypertension, and occurrence of death. CHD was ascertained through ongoing surveillance of heart disease in Olmsted County. Cox proportional hazard models were used to estimate associations between baseline nocturia and each of the outcomes.
RESULTS: A total of 2447 men were followed for a median of 17.1 years (25th and 75th percentiles: 15.0, 17.4 years). Moderate nocturia was not significantly associated with the later development of diabetes mellitus or hypertension in this study. Younger men (<60 years of age) with moderate nocturia were more likely to develop CHD later in life than younger men without nocturia (hazard ratio [HR]: 1.68; 95% confidence interval [CI]: 1.13, 2.49). This association was no longer significant when adjusted for age, body mass index (BMI) and urological medications (HR: 1.36; 95% CI: 0.87, 2.12). Older men (≥60 years of age) with moderate nocturia were more likely to die than older men without moderate nocturia, even after adjusting for age, BMI, urological medications and CHD (HR: 1.48; 95% CI: 1.15, 1.91).
CONCLUSION: Nocturia may be a marker for increased risk of CHD in younger men, and death in older men.
Authors:
Deborah J Lightner; Amy E Krambeck; Debra J Jacobson; Michaela E McGree; Steven J Jacobsen; Michael M Lieber; Véronique L Roger; Cynthia J Girman; Jennifer L St Sauver
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Publication Detail:
Type:  Journal Article     Date:  2012-01-10
Journal Detail:
Title:  BJU international     Volume:  110     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2012-10-31     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  848-53     Citation Subset:  IM    
Copyright Information:
© 2012 MAYO CLINIC AND MERCK SHARP & DOHME CORP.
Affiliation:
Department of Urology, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Coronary Artery Disease / etiology*,  mortality*
Diabetes Mellitus / etiology
Humans
Hypertension / etiology
Male
Middle Aged
Nocturia / complications*
Retrospective Studies
Risk Assessment
Grant Support
ID/Acronym/Agency:
R01 AG034676/AG/NIA NIH HHS; R01 AR030582/AR/NIAMS NIH HHS; R01 DK058859/DK/NIDDK NIH HHS
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