Document Detail


Nociceptive sensory neurons derive from contralaterally migrating, fate-restricted neural crest cells.
MedLine Citation:
PMID:  17828258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neural crest cells (NCCs) are a transient population of multipotent progenitors that give rise to numerous cell types in the embryo. An unresolved issue is the degree to which the fate of NCCs is specified prior to their emigration from the neural tube. In chick embryos, we identified a subpopulation of NCCs that, upon delamination, crossed the dorsal midline to colonize spatially discrete regions of the contralateral dorsal root ganglia (DRG), where they later gave rise to nearly half of the nociceptor sensory neuron population. Our data indicate that before emigration, this NCC subset is phenotypically distinct, with an intrinsic lineage potential that differs from its temporally synchronized, but ipsilaterally migrating, cohort. These findings not only identify a major source of progenitor cells for the pain- and temperature-sensing afferents, but also reveal a previously unknown migratory pathway for sensory-fated NCCs that requires the capacity to cross the embryonic midline.
Authors:
Lynn George; Marta Chaverra; Valerie Todd; Rusty Lansford; Frances Lefcort
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-09-02
Journal Detail:
Title:  Nature neuroscience     Volume:  10     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-25     Completed Date:  2008-01-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1287-93     Citation Subset:  IM    
Affiliation:
Department of Cell Biology and Neuroscience, Montana State University, Leon Johnson Hall, Rm 512, Bozeman, Montana 59717, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology
Cell Movement / physiology*
Chick Embryo
Functional Laterality / physiology*
Ganglia, Spinal / cytology,  embryology
Gene Expression Regulation, Developmental / physiology
Neural Crest / cytology*,  embryology*
Neural Tube / cytology,  embryology
Neurons, Afferent / physiology*
Receptor, trkA / metabolism
Stem Cells / physiology*
Grant Support
ID/Acronym/Agency:
NRSA 7055571//PHS HHS; R01 35714//PHS HHS
Chemical
Reg. No./Substance:
EC 2.7.10.1/Receptor, trkA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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