Document Detail

Nociceptin, an endogenous ligand for the ORL1 receptor, has vasodilator activity in the hindquarters vascular bed of the rat.
MedLine Citation:
PMID:  9285926     Owner:  NLM     Status:  MEDLINE    
The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the G-protein coupled, opioid-like receptor ORL1. In the present study, responses to intra-arterial injections of nociceptin were investigated in the hindquarters vascular bed of the rat. Under constant-flow conditions nociceptin induced dose-dependent decreases in hindquarters perfusion pressure when injected in doses of 1-30 nmol into the hindquarters perfusion circuit. The decreases in hindquarters perfusion pressure were rapid in onset and pressure returned to control values over a 3-6 min period. In terms of relative vasodilator activity, nociceptin was approximately equipotent to the nitric oxide donor, DEA/NO, and 30-fold less potent than adrenomedullin. These data demonstrate that nociceptin has significant vasodilator activity in the hindquarters vascular bed of the rat.
M A Czapla; H C Champion; P J Kadowitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  18     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-18     Completed Date:  1998-02-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  793-5     Citation Subset:  IM    
Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
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MeSH Terms
Hindlimb / blood supply
Hydrazines / pharmacology
Injections, Intra-Arterial
Nitrogen Oxides
Opioid Peptides / administration & dosage,  metabolism,  pharmacology*
Peptides / pharmacology
Rats, Sprague-Dawley
Receptors, Opioid / agonists*,  metabolism*
Vasoactive Intestinal Peptide / pharmacology
Vasodilator Agents / pharmacology*
Grant Support
Reg. No./Substance:
0/Hydrazines; 0/Ligands; 0/Nitrogen Oxides; 0/Opioid Peptides; 0/Peptides; 0/Receptors, Opioid; 0/Vasodilator Agents; 0/nociceptin; 0/nociceptin receptor; 148498-78-6/Adrenomedullin; 37221-79-7/Vasoactive Intestinal Peptide; 86831-65-4/1,1-diethyl-2-hydroxy-2-nitrosohydrazine

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