Document Detail

Nocardia asteroides isolated from three patients with cystic fibrosis.
MedLine Citation:
PMID:  11957029     Owner:  NLM     Status:  MEDLINE    
Over a 7-year period, three patients with cystic fibrosis had multiple sputum specimens that were smear- and culture-positive for Nocardia asteroides. Two of the patients had received long-term, low-dose inhalational corticosteroid therapy. Although all three patients were treated with cotrimoxazole, resulting in eradication of the organism from the sputum, there was no change in their clinical state, radiological findings, or pulmonary function. The isolation of Nocardia asteroides from the respiratory tract of cystic fibrosis patients is an unusual finding. Its presence does not necessarily imply disease, and in these three cases, it most likely represented colonisation. The clinical significance of Nocardia spp. isolated from the respiratory tract of cystic fibrosis patients needs to be considered in the context of the individual clinical picture.
R Lumb; H Greville; J Martin; N Sangster; M Holmes
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2002-03-20
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  21     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-16     Completed Date:  2002-05-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  230-3     Citation Subset:  IM    
Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, PO Box 14, Rundle Mall, Adelaide, South Australia 5001, Australia.
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MeSH Terms
Adrenal Cortex Hormones / adverse effects
Anti-Bacterial Agents / therapeutic use
Carrier State / microbiology*
Cystic Fibrosis / complications*,  microbiology*
Immunosuppressive Agents / adverse effects
Nocardia Infections / complications*,  drug therapy,  microbiology*
Nocardia asteroides / isolation & purification*
Trimethoprim-Sulfamethoxazole Combination / therapeutic use
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anti-Bacterial Agents; 0/Immunosuppressive Agents; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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