| Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. | |
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MedLine Citation:
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PMID: 11804785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To identify novel genes involved in early mammalian folliculogenesis, we used the Unigene collection of mouse cDNA libraries to identify unique expressed sequence tags in a newborn mouse ovary cDNA library. Nobox (newborn ovary homeobox-encoding gene) was one of several genes identified by in silico (electronic database) subtraction. We cloned the mouse Nobox cDNA and characterized its genomic organization. The gene spans 14kb and is encoded by eight exons. The Nobox gene maps to proximal chromosome 6 in the mouse, and we identified a portion of the human gene encoding a NOBOX homolog which resides at a syntenic position on chromosome 7q35. Reverse transcriptase polymerase chain reaction and Northern blot analyses show that Nobox is preferentially expressed in the ovary at high levels. In situ hybridization analysis demonstrates that Nobox mRNA is present in primordial and growing oocytes. Nobox is one of the first homeobox-encoding genes preferentially expressed during mammalian folliculogenesis. |
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Authors:
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Nobuhiro Suzumori; Changning Yan; Martin M Matzuk; Aleksandar Rajkovic |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mechanisms of development Volume: 111 ISSN: 0925-4773 ISO Abbreviation: Mech. Dev. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-01-23 Completed Date: 2002-06-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9101218 Medline TA: Mech Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 137-41 Citation Subset: IM |
Affiliation:
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Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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PDB/AY061761 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Blotting, Northern Chromosome Mapping Chromosomes, Human, Pair 7 Cloning, Molecular Expressed Sequence Tags Female Gene Order Homeodomain Proteins / genetics*, metabolism* Humans In Situ Hybridization Male Mice Mice, Inbred C57BL Molecular Sequence Data Oocytes / physiology* Reverse Transcriptase Polymerase Chain Reaction Sequence Homology, Amino Acid Transcription Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD00849/HD/NICHD NIH HHS; HD33438/HD/NICHD NIH HHS; HD37231/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/Og2x protein, mouse; 0/Transcription Factors |
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