Document Detail

Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes.
MedLine Citation:
PMID:  11804785     Owner:  NLM     Status:  MEDLINE    
To identify novel genes involved in early mammalian folliculogenesis, we used the Unigene collection of mouse cDNA libraries to identify unique expressed sequence tags in a newborn mouse ovary cDNA library. Nobox (newborn ovary homeobox-encoding gene) was one of several genes identified by in silico (electronic database) subtraction. We cloned the mouse Nobox cDNA and characterized its genomic organization. The gene spans 14kb and is encoded by eight exons. The Nobox gene maps to proximal chromosome 6 in the mouse, and we identified a portion of the human gene encoding a NOBOX homolog which resides at a syntenic position on chromosome 7q35. Reverse transcriptase polymerase chain reaction and Northern blot analyses show that Nobox is preferentially expressed in the ovary at high levels. In situ hybridization analysis demonstrates that Nobox mRNA is present in primordial and growing oocytes. Nobox is one of the first homeobox-encoding genes preferentially expressed during mammalian folliculogenesis.
Nobuhiro Suzumori; Changning Yan; Martin M Matzuk; Aleksandar Rajkovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mechanisms of development     Volume:  111     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-23     Completed Date:  2002-06-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM    
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Blotting, Northern
Chromosome Mapping
Chromosomes, Human, Pair 7
Cloning, Molecular
Expressed Sequence Tags
Gene Order
Homeodomain Proteins / genetics*,  metabolism*
In Situ Hybridization
Mice, Inbred C57BL
Molecular Sequence Data
Oocytes / physiology*
Reverse Transcriptase Polymerase Chain Reaction
Sequence Homology, Amino Acid
Transcription Factors
Grant Support
Reg. No./Substance:
0/Homeodomain Proteins; 0/Og2x protein, mouse; 0/Transcription Factors

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